Enantioselective ring opening of aza and oxabicyclic alkenes with dimethylzinc

被引：97

作者：

Lautens, M ^{[1
]}

Hiebert, S ^{[1
]}

Renaud, JL ^{[1
]}

机构：

[1] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 13期

关键词：

D O I：

10.1021/ol006052a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A system for efficient, asymmetric alkylative ring opening of azabenzonorbornadienes and [2.2.1] and [3.2.1] oxabicyclic alkenes was developed, The use of Pd(CH3CN)(2)Cl-2 and chiral phosphinooxazoline ligands gives the dihydronaphthalenes, cyclohexenols, and cycloheptenols in excellent yields and enantiomeric excesses.

引用

页码：1971 / 1973

页数：3

共 14 条

[11]

SPINZ J, 1993, TETRAHEDRON LETT, V34, P1769

[12] CHIRAL PHOSPHINOARYLDIHYDROOXAZOLES AS LIGANDS IN ASYMMETRIC CATALYSIS - PD-CATALYZED ALLYLIC SUBSTITUTION [J].