A novel synthesis of some 2-imino-4-thiazolidinone derivatives

被引：20

作者：

Moghaddam, Firouz Matloubi ^{[1
]}

Hojabri, Leila ^{[1
]}

机构：

[1] Sharif Univ Technol, Dept Chem, Tehran, Iran

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2007年 / 44卷 / 01期

关键词：

D O I：

10.1002/jhet.5570440106

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and simple route is presented to the synthesis of some iminothiazolidinone derivatives. alpha-Chloro amide derivatives undergo coupling reaction with isothiocyanate in the presence of a mild base, followed by nucleophilic substitution of chlorine by the sulfur atom of isothiocyanate.

引用

收藏

页码：35 / 38

页数：4

相关论文

共 22 条

[11]

Klika KD, 2002, EUR J ORG CHEM, V2002, P1248

[12] Synthesis, characterisation and biological activity of novel 4-thiazolidinones, 1,3,4-oxadiazoles and some related compounds [J].

Küçükgüzel, SG ;

Oruç, EE ;

Rollas, S ;

Sahin, F ;

Özbek, A .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2002, 37 (03) :197-206

[13]

LASZLO P, 1995, ORGANIC REACIONS SIM

[14] Synthesis and fungicidal activity of 2-imino-3-(4-arylthiazol-2-yl)-thiazolidin-4-ones and their 5-arylidene derivatives [J].

Liu, HL ;

Li, ZC ;

Anthonsen, T .

MOLECULES, 2000, 5 (09) :1055-1061

[15]

NAJOR H, 1963, B SOC CHIM FR, P1018

[16]

Romine J.L., 2004, World Patent Application, Patent No. [WO-2004/014852, 2004014852]

[17] Synthesis and ring transformation of substituted S-(1-phenylpyrrolidine-2-ones-3-yl)isothiuronium salts to substituted 2-imino-5-[2-(phenylamino)ethyl]thiazolidin-4-ones [J].

Sedlák, M ;

Hejtmánková, L ;

Hanusek, J ;

Machácek, V .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 2002, 39 (05) :1105-1107

[18] PPAR-γ:: Adipogenic regulator and thiazolidinedione receptor [J].

Spiegelman, BM .

DIABETES, 1998, 47 (04) :507-514

[19] Regioselective synthesis of 3-(heteroaryl)-iminothiazolidin-4-ones [J].

St Laurent, DR ;

Gao, Q ;

Wu, DD ;

Serrano-Wu, MH .

TETRAHEDRON LETTERS, 2004, 45 (09) :1907-1910

[20] SYNTHESIS AND BIOLOGICAL EVALUATION OF 5-[[3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXYPHENYL]METHYLENE]OXAZOLES, -THIAZOLES, AND -IMIDAZOLES - NOVEL DUAL 5-LIPOXYGENASE AND CYCLOOXYGENASE INHIBITORS WITH ANTIINFLAMMATORY ACTIVITY [J].

UNANGST, PC ;

CONNOR, DT ;

CETENKO, WA ;

SORENSON, RJ ;

KOSTLAN, CR ;

SIRCAR, JC ;

WRIGHT, CD ;

SCHRIER, DJ ;

DYER, RD .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (02) :322-328