2,5-dimethylphenacyl as a new photoreleasable protecting group for carboxylic acids

被引：51

作者：

Klán, P ^{[1
]}

Zabadal, M ^{[1
]}

Heger, D ^{[1
]}

机构：

[1] Masaryk Univ, Fac Sci, Dept Organ Chem, CS-61137 Brno, Czech Republic

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 11期

关键词：

D O I：

10.1021/ol005789x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The 2,5-dimethylphenacyl chromophore, a new photoremovable protecting group for carboxylic acids, is proposed. Direct photolysis of various 2,5-dimethylphenacyl esters in benzene or methanol at 254-366 nm leads to the formation of the corresponding carboxylic acids in almost quantitative isolated yields. The photodeprotection is based on efficient intramolecular hydrogen abstraction without the necessity of introducing a photosensitizer.

引用

页码：1569 / 1571

页数：3

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