Increased expression of N-myc downstream-regulated gene 1 (NDRG1) in placentas from pregnancies complicated by intrauterine growth restriction or preeclampsia

被引：27

作者：

Choi, Suk-Joo ^{[1
]}

Oh, Soo-young

Kim, Jong-Hwa

Sadovsky, Yoel

Roh, Cheong-Rae

机构：

[1] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Obstet & Gynecol, Seoul, South Korea

[2] Washington Univ, Sch Med, Dept Obstet & Gynecol, St Louis, MO 63130 USA

[3] Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USA

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2007年 / 196卷 / 01期

基金：

美国国家卫生研究院;

关键词：

intrauterine growth restriction; N-myc downstream-regulated gene; placenta; preeclampsia;

D O I：

10.1016/j.ajog.2006.08.029

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

N-myc downstream-regulated gene 1 is a recently identified gene product that is known to have a role in regulation of trophoblast differentiation and response to injury. By using immuno-staining, Western immunoblotting, and real-time quantitative polymerase chain reaction, we found that the expression of N-myc downstream-regulated gene 1 is upregulated in placentas from pregnancies complicated by intrauterine growth restriction or severe preeclampsia.

引用

页码：45 / 47

页数：3

共 20 条

[11]

Xu B., Lin L., Rote N.S., Identification of a stress-induced protein during human trophoblast differentiation by differential display analysis, Biol Reprod, 61, pp. 681-686, (1999)

[12]

Gratton R.J., Gluszynski M., Nygard K., Mazzuca D.M., Graham C.H., Han V.K., Reducing agent and tunicamycin-responsive protein (RTP) mRNA expression in the placentae of normal and pre-eclamptic women, Placenta, 25, pp. 62-69, (2004)

[13]

Park H., Adams M.A., Lachat P., Bosman F., Pang S.C., Graham C.H., Hypoxia induces the expression of a 43-kDa protein (PROXY-1) in normal and malignant cells, Biochem Biophys Res Commun, 276, pp. 321-328, (2000)

[14]

Chen B., Nelson D.M., Sadovsky Y., N-Myc downregulated gene 1 (Ndrg1) modulates the response of term human trophoblasts to hypoxic injury, J Biol Chem, 281, pp. 2764-2772, (2006)

[15]

Roh C.R., Budhraja V., Kim H.S., Nelson D.M., Sadovsky Y., Microarray-based identification of differentially expressed genes in hypoxic term human trophoblasts and in placental villi of pregnancies with growth restricted fetuses, Placenta, 26, pp. 319-328, (2005)

[16]

Thompson R.S., Trudinger B.J., Cook C.M., Giles W.B., Umbilical artery velocity waveforms: normal reference values for A/B ratio and Pourcelot ratio, BJOG, 95, pp. 589-591, (1988)

[17]

Wyatt S.M., Kraus F.T., Roh C.R., Elchalal U., Nelson D.M., Sadovsky Y., The correlation between sampling site and gene expression in the term human placenta, Placenta, 26, pp. 372-379, (2005)

[18]

Kurdistani S.K., Arizti P., Reimer C.L., Sugrue M.M., Aaronson S.A., Lee S.W., Inhibition of tumor cell growth by RTP/rit42 and its responsiveness to p53 and DNA damage, Cancer Res, 58, pp. 4439-4444, (1998)

[19]

Rogers B.B., Bloom S.L., Leveno K.J., Atherosis revisited: current concepts on the pathophysiology of implantation site disorders, Obstet Gynecol Surv, 54, pp. 189-195, (1999)

[20]

Baschat A.A., Pathophysiology of fetal growth restriction: implications for diagnosis and surveillance, Obstet Gynecol Surv, 59, pp. 617-627, (2004)

← 1 2 →