TISSUE-SPECIFIC IMMUNE RESPONSES Tissue-mediated control of immunopathology in coeliac disease

被引：227

作者：

Jabri, Bana ^{[1
,2
]}

Sollid, Ludvig M. ^{[3
,4
]}

机构：

[1] Univ Chicago, Dept Med, Dept Pathol, Chicago, IL 60637 USA

[2] Univ Chicago, Dept Pediat, Chicago, IL 60637 USA

[3] Univ Oslo, Ctr Immune Regulat, Inst Immunol, N-0027 Oslo, Norway

[4] Oslo Univ Hosp, Rikshosp, N-0027 Oslo, Norway

来源：

NATURE REVIEWS IMMUNOLOGY | 2009年 / 9卷 / 12期

基金：

美国国家卫生研究院;

关键词：

T-CELL RESPONSE; INTESTINAL EPITHELIAL-CELLS; CHRONIC HEPATITIS-C; DENDRITIC CELLS; INTRAEPITHELIAL LYMPHOCYTES; DIABETES-MELLITUS; GLIADIN PEPTIDES; INTERFERON-ALPHA; STRUCTURAL BASIS; NATURAL-KILLER;

D O I：

10.1038/nri2670

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Coeliac disease is an inflammatory disorder with autoimmune features that is characterized by destruction of the intestinal epithelium and remodelling of the intestinal mucosa following the ingestion of dietary gluten. A common feature of coeliac disease and many organ-specific autoimmune diseases is a central role for T cells in causing tissue destruction. In this Review, we discuss the emerging hypothesis that, in coeliac disease, intestinal tissue inflammation-induced either by infectious agents or by gluten-is crucial for activating T cells and eliciting their tissue-destructive effector functions.

引用

页码：858 / 870

页数：13

共 122 条

[31] INTRAEPITHELIAL T-CELLS OF THE TCR-GAMMA/DELTA+CD8- AND V-DELTA-1/J-DELTA-1+ PHENOTYPES ARE INCREASED IN CELIAC-DISEASE [J].

HALSTENSEN, TS ;

SCOTT, H ;

BRANDTZAEG, P .

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1989, 30 (06) :665-672

[32] A structural and immunological basis for the role of human leukocyte antigen DQ8 in celiac disease [J].

Henderson, Kate N. ;

Tye-Din, Jason A. ;

Reid, Hugh H. ;

Chen, Zhenjun ;

Borg, Natalie A. ;

Beissbarth, Tim ;

Tatham, Arthur ;

Mannering, Stuart I. ;

Purcell, Anthony W. ;

Dudek, Nadine L. ;

van Heel, David A. ;

McCluskey, James ;

Rossjohn, Jamie ;

Anderson, Robert P. .

IMMUNITY, 2007, 27 (01) :23-34

[33] T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation [J].

Henrickson, Sarah E. ;

Mempel, Thorsten R. ;

Mazo, Irina B. ;

Liu, Bai ;

Artyomov, Maxim N. ;

Zheng, Huan ;

Peixoto, Antonio ;

Flynn, Michael P. ;

Senman, Balimkiz ;

Junt, Tobias ;

Wong, Hing C. ;

Chakraborty, Arup K. ;

von Andrian, Ulrich H. .

NATURE IMMUNOLOGY, 2008, 9 (03) :282-291

[34] The role of HLA-DQ8 β57 polymorphism in the anti-gluten T-cell response in coeliac disease [J].

Hovhannisyan, Zaruhi ;

Weiss, Angela ;

Martin, Alexandra ;

Wiesner, Martina ;

Tollefsen, Stig ;

Yoshida, Kenji ;

Ciszewski, Cezary ;

Curran, Shane A. ;

Murray, Joseph A. ;

David, Chella S. ;

Sollid, Ludvig M. ;

Koning, Frits ;

Teyton, Luc ;

Jabri, Bana .

NATURE, 2008, 456 (7221) :534-538

[35] A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease [J].

Hüe, S ;

Mention, JJ ;

Monteiro, RC ;

Zhang, SL ;

Cellier, C ;

Schmitz, J ;

Verkarre, V ;

Fodil, N ;

Bahram, S ;

Cerf-Bensussan, N ;

Caillat-Zucman, S .

IMMUNITY, 2004, 21 (03) :367-377

[36] Newly identified genetic risk variants for celiac disease related to the immune response [J].

Hunt, Karen A. ;

Zhernakova, Alexandra ;

Turner, Graham ;

Heap, Graham A. R. ;

Franke, Lude ;

Bruinenberg, Marcel ;

Romanos, Jihane ;

Dinesen, Lotte C. ;

Ryan, Anthony W. ;

Panesar, Davinder ;

Gwilliam, Rhian ;

Takeuchi, Fumihiko ;

McLaren, William M. ;

Holmes, Geoffrey K. T. ;

Howdle, Peter D. ;

Walters, Julian R. F. ;

Sanders, David S. ;

Playford, Raymond J. ;

Trynka, Gosia ;

Mulder, Chris J. J. ;

Mearin, M. Luisa ;

Verbeek, Wieke H. M. ;

Trimble, Valerie ;

Stevens, Fiona M. ;

O'Morain, Colm ;

Kennedy, Nicholas P. ;

Kelleher, Dermot ;

Pennington, Daniel J. ;

Strachan, David P. ;

McArdle, Wendy L. ;

Mein, Charles A. ;

Wapenaar, Martin C. ;

Deloukas, Panos ;

McGinnis, Ralph ;

McManus, Ross ;

Wijmenga, Cisca ;

van Heel, David A. .

NATURE GENETICS, 2008, 40 (04) :395-402

[37]

HUSBY S, 1994, J IMMUNOL, V152, P4663

[38] The yin and yang of intestinal epithelial cells in controlling dendritic cell function [J].

Iliev, Iliyan D. ;

Matteoli, Gianluca ;

Rescigno, Maria .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (10) :2253-2257

[39] Selective expansion of intraepithelial lymphocytes expressing the HLA-E-specific natural killer receptor CD94 in celiac disease [J].

Jabri, B ;

De Serre, NPM ;

Cellier, C ;

Evans, K ;

Gache, C ;

Carvalho, C ;

Mougenot, JF ;

Allez, M ;

Jian, R ;

Desreumaux, P ;

Colombel, JF ;

Matuchansky, C ;

Cugnenc, H ;

Lopez-Botet, M ;

Vivier, E ;

Moretta, A ;

Roberts, AI ;

Ebert, EC ;

Guy-Grand, D ;

Brousse, N ;

Schmitz, J ;

Cerf-Bensussan, N .

GASTROENTEROLOGY, 2000, 118 (05) :867-879

[40] TCR specificity dictates CD94/NKG2A expression by human CTL [J].

Jabri, B ;

Selby, JM ;

Negulescu, H ;

Lee, L ;

Roberts, AI ;

Beavis, A ;

Lopez-Botet, M ;

Ebert, EC ;

Winchester, RJ .

IMMUNITY, 2002, 17 (04) :487-499

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