An efficient and high yielding protocol for the synthesis of substituted dihydropyrimidin-2(1H)-ones and spiro-fused heterocycles by involving tandem reactions

被引：12

作者：

Bose, D. Subhas ^{[1
]}

Idrees, Mohd. ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem 3, Fine Chem Lab, Hyderabad 500007, Andhra Pradesh, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2007年 / 44卷 / 01期

关键词：

D O I：

10.1002/jhet.5570440133

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient method has been developed for the synthesis of 3,4-dihydropyrimidin2(1H)-ones by a one-pot three component cyclocondensation reaction of alkyl acetoacetates, aldehyde, and urea in the presence of a catalytic amount of the reusable catalyst zinc per chlorate hexahydrate, Zn(ClO4)(2).6H(2)O (10 mol %) the scope of this protocol is utilized for the synthesis of mitotic Kinesin EG5 inhibitor monastrol and new class of fused heterobicyclic compounds in high yields.

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页码：211 / 214

页数：4

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