Sensitivity of Salivary Glands to Radiation: from Animal Models to Therapies

被引：180

作者：

Grundmann, O. ^{[1
]}

Mitchell, G. C. ^{[2
]}

Limesand, K. H. ^{[1
,2
]}

机构：

[1] Univ Arizona, Dept Nutr Sci, Tucson, AZ 85721 USA

[2] Univ Arizona, Canc Biol Program, Tucson, AZ 85721 USA

来源：

JOURNAL OF DENTAL RESEARCH | 2009年 / 88卷 / 10期

关键词：

radiation; salivary gland dysfunction; salivary glands; animal models; therapy; xerostomia; INTENSITY-MODULATED RADIOTHERAPY; PAROTID-SPARING RADIOTHERAPY; ADENOVIRAL-MEDIATED TRANSFER; IRRADIATION-INDUCED DAMAGE; INCREASED FLUID SECRETION; HUMAN AQUAPORIN-1 CDNA; LOCALLY ADVANCED HEAD; KINASE-C-DELTA; NECK-CANCER; SUBMANDIBULAR-GLAND;

D O I：

10.1177/0022034509343143

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Radiation therapy for head and neck cancer causes significant secondary side-effects in normal salivary glands, resulting in diminished quality of life for these individuals. Salivary glands are exquisitely sensitive to radiation and display acute and chronic responses to radiotherapy. This review will discuss clinical implications of radiosensitivity in normal salivary glands, compare animal models used to investigate radiation-induced salivary gland damage, address therapeutic advances, and project future directions in the field.

引用

页码：894 / 903

页数：10

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