共 75 条
Molecular basis of epithelial barrier regulation - From basic mechanisms to clinical application
被引:449
作者:

Turner, Jerrold R.
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机构:
Univ Chicago, Dept Pathol, Chicago, IL 60637 USA Univ Chicago, Dept Pathol, Chicago, IL 60637 USA
机构:
[1] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA
关键词:
D O I:
10.2353/ajpath.2006.060681
中图分类号:
R36 [病理学];
学科分类号:
100104 ;
摘要:
The intestinal epithelium is faced with the complex task of providing a barrier while also allowing nutrient and water absorption. The frequency with which these processes are disrupted in disease can be taken as evidence of their importance. It is therefore of interest to define die mechanisms of altered intestinal barrier and transport function and develop means to correct disease-associated defects. over the past 10 years, some of die molecular events underlying physiological epithelial barrier regulation have been described. Remarkably, recent advances have shown that activation of the same mechanisms is central to barrier dysfunction in both in vitro and in vivo models of disease. Although the contribution of barrier dysfunction to pathogenesis of chronic disease remains incompletely understood, it is now clear that cytoskeletal regulation of barrier function is both an important pathogenic process and that targeted inhibition of myosin light chain kinase, which affects this cytoskeleton-dependent tight junction dysfunction, is an attractive candidate for therapeutic intervention.
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页码:1901 / 1909
页数:9
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共 75 条
[11]
The two faces of IKK and NF-κB inhibition:: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion
[J].
Chen, LW
;
Egan, L
;
Li, ZW
;
Greten, FR
;
Kagnoff, MF
;
Karin, M
.
NATURE MEDICINE,
2003, 9 (05)
:575-581

Chen, LW
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Diego, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, San Diego, CA 92103 USA

Egan, L
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Diego, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, San Diego, CA 92103 USA

Li, ZW
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Diego, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, San Diego, CA 92103 USA

Greten, FR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Diego, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, San Diego, CA 92103 USA

Kagnoff, MF
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Diego, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, San Diego, CA 92103 USA

Karin, M
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, San Diego, CA 92103 USA Univ Calif San Diego, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, San Diego, CA 92103 USA
[12]
Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo
[J].
Clayburgh, DR
;
Barrett, TA
;
Tang, YM
;
Meddings, JB
;
Van Eldik, LJ
;
Watterson, DM
;
Clarke, LL
;
Mrsny, RJ
;
Turner, JR
.
JOURNAL OF CLINICAL INVESTIGATION,
2005, 115 (10)
:2702-2715

Clayburgh, DR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

Barrett, TA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

Tang, YM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

Meddings, JB
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

Van Eldik, LJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

Watterson, DM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

Clarke, LL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

Mrsny, RJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

Turner, JR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Pathol, Chicago, IL 60637 USA
[13]
A porous defense: the leaky epithelial barrier in intestinal disease
[J].
Clayburgh, DR
;
Shen, L
;
Turner, JR
.
LABORATORY INVESTIGATION,
2004, 84 (03)
:282-291

Clayburgh, DR
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Chicago, Dept Pathol, Chicago, IL 60637 USA Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

Shen, L
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Chicago, Dept Pathol, Chicago, IL 60637 USA Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

Turner, JR
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Chicago, Dept Pathol, Chicago, IL 60637 USA Univ Chicago, Dept Pathol, Chicago, IL 60637 USA
[14]
A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability
[J].
Clayburgh, DR
;
Rosen, S
;
Witkowski, ED
;
Wang, FJ
;
Blair, S
;
Dudek, S
;
Garcia, JGN
;
Alverdy, JC
;
Turner, JR
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2004, 279 (53)
:55506-55513

Clayburgh, DR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

Rosen, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

Witkowski, ED
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

Wang, FJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

Blair, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

Dudek, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

Garcia, JGN
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

论文数: 引用数:
h-index:
机构:

Turner, JR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Pathol, Chicago, IL 60637 USA
[15]
Intestinal permeability test as a predictor of clinical course in Crohn's disease
[J].
D'Incà, R
;
Di Leo, V
;
Corrao, G
;
Martines, D
;
D'Odorico, A
;
Mestriner, C
;
Venturi, C
;
Longo, G
;
Sturniolo, GC
.
AMERICAN JOURNAL OF GASTROENTEROLOGY,
1999, 94 (10)
:2956-2960

D'Incà, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Padua, Div Gastroenterol, I-35100 Padua, Italy

Di Leo, V
论文数: 0 引用数: 0
h-index: 0
机构: Univ Padua, Div Gastroenterol, I-35100 Padua, Italy

Corrao, G
论文数: 0 引用数: 0
h-index: 0
机构: Univ Padua, Div Gastroenterol, I-35100 Padua, Italy

Martines, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Padua, Div Gastroenterol, I-35100 Padua, Italy

D'Odorico, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Padua, Div Gastroenterol, I-35100 Padua, Italy

Mestriner, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Padua, Div Gastroenterol, I-35100 Padua, Italy

Venturi, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Padua, Div Gastroenterol, I-35100 Padua, Italy

论文数: 引用数:
h-index:
机构:

Sturniolo, GC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Padua, Div Gastroenterol, I-35100 Padua, Italy
[16]
Disseminated tuberculosis complicating anti-TNF-α treatment
[J].
Dimakou, K
;
Papaioannides, D
;
Latsi, P
;
Katsimboula, S
;
Korantzopoulos, P
;
Orphanidou, D
.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE,
2004, 58 (11)
:1052-1055

Dimakou, K
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Athens, Sch Med, Sotiria Hosp, Dept Resp Med, GR-10679 Athens, Greece Univ Athens, Sch Med, Sotiria Hosp, Dept Resp Med, GR-10679 Athens, Greece

Papaioannides, D
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Athens, Sch Med, Sotiria Hosp, Dept Resp Med, GR-10679 Athens, Greece Univ Athens, Sch Med, Sotiria Hosp, Dept Resp Med, GR-10679 Athens, Greece

Latsi, P
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Athens, Sch Med, Sotiria Hosp, Dept Resp Med, GR-10679 Athens, Greece Univ Athens, Sch Med, Sotiria Hosp, Dept Resp Med, GR-10679 Athens, Greece

Katsimboula, S
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Athens, Sch Med, Sotiria Hosp, Dept Resp Med, GR-10679 Athens, Greece Univ Athens, Sch Med, Sotiria Hosp, Dept Resp Med, GR-10679 Athens, Greece

Korantzopoulos, P
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Athens, Sch Med, Sotiria Hosp, Dept Resp Med, GR-10679 Athens, Greece Univ Athens, Sch Med, Sotiria Hosp, Dept Resp Med, GR-10679 Athens, Greece

Orphanidou, D
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Athens, Sch Med, Sotiria Hosp, Dept Resp Med, GR-10679 Athens, Greece Univ Athens, Sch Med, Sotiria Hosp, Dept Resp Med, GR-10679 Athens, Greece
[17]
REGULATION OF EPITHELIAL TIGHT JUNCTION PERMEABILITY BY CYCLIC-AMP
[J].
DUFFEY, ME
;
HAINAU, B
;
HO, S
;
BENTZEL, CJ
.
NATURE,
1981, 294 (5840)
:451-453

DUFFEY, ME
论文数: 0 引用数: 0
h-index: 0
机构: SUNY BUFFALO,DEPT PHYSIOL,BUFFALO,NY 14215

HAINAU, B
论文数: 0 引用数: 0
h-index: 0
机构: SUNY BUFFALO,DEPT PHYSIOL,BUFFALO,NY 14215

HO, S
论文数: 0 引用数: 0
h-index: 0
机构: SUNY BUFFALO,DEPT PHYSIOL,BUFFALO,NY 14215

BENTZEL, CJ
论文数: 0 引用数: 0
h-index: 0
机构: SUNY BUFFALO,DEPT PHYSIOL,BUFFALO,NY 14215
[18]
Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice
[J].
Furuse, M
;
Hata, M
;
Furuse, K
;
Yoshida, Y
;
Haratake, A
;
Sugitani, Y
;
Noda, T
;
Kubo, A
;
Tsukita, S
.
JOURNAL OF CELL BIOLOGY,
2002, 156 (06)
:1099-1111

Furuse, M
论文数: 0 引用数: 0
h-index: 0
机构: Kyoto Univ, Fac Med, Dept Cell Biol, Sakyo Ku, Kyoto 6068501, Japan

Hata, M
论文数: 0 引用数: 0
h-index: 0
机构: Kyoto Univ, Fac Med, Dept Cell Biol, Sakyo Ku, Kyoto 6068501, Japan

Furuse, K
论文数: 0 引用数: 0
h-index: 0
机构: Kyoto Univ, Fac Med, Dept Cell Biol, Sakyo Ku, Kyoto 6068501, Japan

Yoshida, Y
论文数: 0 引用数: 0
h-index: 0
机构: Kyoto Univ, Fac Med, Dept Cell Biol, Sakyo Ku, Kyoto 6068501, Japan

Haratake, A
论文数: 0 引用数: 0
h-index: 0
机构: Kyoto Univ, Fac Med, Dept Cell Biol, Sakyo Ku, Kyoto 6068501, Japan

Sugitani, Y
论文数: 0 引用数: 0
h-index: 0
机构: Kyoto Univ, Fac Med, Dept Cell Biol, Sakyo Ku, Kyoto 6068501, Japan

Noda, T
论文数: 0 引用数: 0
h-index: 0
机构: Kyoto Univ, Fac Med, Dept Cell Biol, Sakyo Ku, Kyoto 6068501, Japan

Kubo, A
论文数: 0 引用数: 0
h-index: 0
机构: Kyoto Univ, Fac Med, Dept Cell Biol, Sakyo Ku, Kyoto 6068501, Japan

Tsukita, S
论文数: 0 引用数: 0
h-index: 0
机构:
Kyoto Univ, Fac Med, Dept Cell Biol, Sakyo Ku, Kyoto 6068501, Japan Kyoto Univ, Fac Med, Dept Cell Biol, Sakyo Ku, Kyoto 6068501, Japan
[19]
Leaks in the epithelial barrier caused by spontaneous and TNF-α-induced single-cell apoptosis
[J].
Gitter, AH
;
Bendfeldt, K
;
Schulzke, JD
;
Fromm, M
.
FASEB JOURNAL,
2000, 14 (12)
:1749-1753

Gitter, AH
论文数: 0 引用数: 0
h-index: 0
机构:
Free Univ Berlin, Klinikum Benjamin Franklin, Inst Klin Physiol, D-12200 Berlin, Germany Free Univ Berlin, Klinikum Benjamin Franklin, Inst Klin Physiol, D-12200 Berlin, Germany

Bendfeldt, K
论文数: 0 引用数: 0
h-index: 0
机构: Free Univ Berlin, Klinikum Benjamin Franklin, Inst Klin Physiol, D-12200 Berlin, Germany

Schulzke, JD
论文数: 0 引用数: 0
h-index: 0
机构: Free Univ Berlin, Klinikum Benjamin Franklin, Inst Klin Physiol, D-12200 Berlin, Germany

Fromm, M
论文数: 0 引用数: 0
h-index: 0
机构: Free Univ Berlin, Klinikum Benjamin Franklin, Inst Klin Physiol, D-12200 Berlin, Germany
[20]
Tumor necrosis factor-induced long myosin light chain kinase transcription is regulated by differentiation-dependent signaling events - Characterization of the human long myosin light chain kinase promoter
[J].
Graham, W. Vallen
;
Wang, Fengjun
;
Clayburgh, Daniel R.
;
Cheng, Jason X.
;
Yoon, Bora
;
Wang, Yingmin
;
Lin, Anning
;
Turner, Jerrold R.
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2006, 281 (36)
:26205-26215

Graham, W. Vallen
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

Wang, Fengjun
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

Clayburgh, Daniel R.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

Cheng, Jason X.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

Yoon, Bora
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

Wang, Yingmin
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

Lin, Anning
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

Turner, Jerrold R.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Chicago, Dept Pathol, Chicago, IL 60637 USA