Roles of Fc receptors in autoimmunity

被引：472

作者：

Takai, T

机构：

[1] Tohoku Univ, Dept Expt Immunol, Sendai, Miyagi 9808575, Japan

[2] Tohoku Univ, Inst Dev Ageing & Canc, Japan Sci & Technol Corp, Core Res Evolut Sci & Technol Programme, Sendai, Miyagi 9808575, Japan

来源：

NATURE REVIEWS IMMUNOLOGY | 2002年 / 2卷 / 08期

关键词：

D O I：

10.1038/nri856

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The receptors for the Fc of immunoglobulins, Fc receptors (FcRs), link the humoral and cellular, branches of the immune system, and they have important functions in the activation and down-modulation of immune responses. Balanced signalling through activating and inhibitory FcRs regulates the activity of various cells in the immune system. Recent work in animal models indicates that the-development of many human autoimmune diseases might be caused by impairment of the FcR regulatory system. This review provides an overview of the mechanisms of FcR-based immune regulation and describes how autoimmune disease might result from its dysfunction.

引用

页码：580 / 592

页数：13

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