Potential role of endothelial progenitor cells in the pathophysiology of heart failure: Clinical implications and perspectives

被引：50

作者：

Andreou, Ioannis ^{[1
]}

Tousoulis, Dimitris ^{[1
]}

Tentolouris, Costas ^{[1
]}

Antoniades, Charalambos ^{[1
]}

Stefanadis, Christodoulos ^{[1
]}

机构：

[1] Univ Athens, Sch Med, A Cardiol Dept, Hippokrat Hosp, Athens 16675, Greece

来源：

ATHEROSCLEROSIS | 2006年 / 189卷 / 02期

关键词：

heart failure; endothelial progenitor cells; endothelium; nitric oxide; inflammation;

D O I：

10.1016/j.atherosclerosis.2006.06.021

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Endothelial dysfunction is thought to play a major role in the development and clinical complications of heart failure. Endothelial progenitor cells (EPCs) have been shown to provide an endogenous repair mechanism to counteract detrimental risk factor-induced effects and replace dysfunctional endothelium. The number and in vitro function of EPCs is altered in patients with heart failure, as a result of its pathophysiological mechanisms. EPCs could represent a substitutional marker to guide preventive or therapeutic interventions in this disease. Enhancing the number and functional capacity of EPCs with targeted interventions may elicit functional improvement in individuals with heart failure. However, the exact role of EPCs in heart failure and their potential therapeutic implications still remain to be elucidated. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：247 / 254

页数：8

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