Nasopharyngeal carcinoma and the EBV-specific T cell response: prospects for immunotherapy

被引：28

作者：

Lee, SP ^{[1
]}

机构：

[1] Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, England

来源：

SEMINARS IN CANCER BIOLOGY | 2002年 / 12卷 / 06期

关键词：

Epstein-Barr virus; immunotherapy; nasopharyngeal carcinoma; T lymphocytes;

D O I：

10.1016/S1044-579X(02)00089-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

T cells specific for Epstein-Barr virus (EBV) can effectively target the virus-transformed B lymphoproliferative lesions that arise in immunosuppressed transplant patients. This review explores the possibility of developing similar T cell-based strategies to treat an EBV-positive epithelial tumour, nasopharyngeal carcinoma (NPC), which arises in relatively immunocompetent individuals and where EBV antigen expression in the tumour is more limited.

引用

页码：463 / 471

页数：9

共 70 条

[1]

AGATHANGGELOU A, 1995, AM J PATHOL, V147, P1152

[2] Expression of cytokine and chemokine genes in Epstein-Barr virus-associated nasopharyngeal carcinoma:: comparison with Hodgkin's disease [J].

Beck, A ;

Päzolt, D ;

Grabenbauer, GG ;

Nicholls, JM ;

Herbst, H ;

Young, LS ;

Niedobitek, G .

JOURNAL OF PATHOLOGY, 2001, 194 (02) :145-151

[3] LYMPHOKINE MESSENGER-RNA PROFILE AND FUNCTIONAL-ANALYSIS OF A HUMAN CD4+ CLONE WITH UNIQUE ANTITUMOR SPECIFICITY ISOLATED FROM RENAL-CELL CARCINOMA ASCITIC FLUID [J].

BELLDEGRUN, A ;

KASID, A ;

UPPENKAMP, M ;

ROSENBERG, SA .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 1990, 31 (01) :1-10

[4] Human CD8+ T cell responses to EBV EBNA1:: HLA class I presentation of the (Gly-Ala)-containing protein requires exogenous processing [J].

Blake, N ;

Lee, S ;

Redchenko, I ;

Thomas, W ;

Steven, N ;

Leese, A ;

Steigerwald-Mullen, P ;

Kurilla, MG ;

Frappier, L ;

Rickinson, A .

IMMUNITY, 1997, 7 (06) :791-802

[5] DIFFERENT HLA-B27 SUBTYPES PRESENT THE SAME IMMUNODOMINANT EPSTEIN-BARR-VIRUS PEPTIDE [J].

BROOKS, JM ;

MURRAY, RJ ;

THOMAS, WA ;

KURILLA, MG ;

RICKINSON, AB .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (03) :879-887

[6] EPSTEIN-BARR-VIRUS LATENT GENE-TRANSCRIPTION IN NASOPHARYNGEAL CARCINOMA-CELLS - COEXPRESSION OF EBNA1, LMP1, AND LMP2 TRANSCRIPTS [J].

BROOKS, L ;

YAO, QY ;

RICKINSON, AB ;

YOUNG, LS .

JOURNAL OF VIROLOGY, 1992, 66 (05) :2689-2697

[7] ELEVATED EXPRESSION OF ICAM1 (CD54) AND MINIMAL EXPRESSION OF LFA3 (CD58) IN EPSTEIN-BARR-VIRUS-POSITIVE NASOPHARYNGEAL CARCINOMA-CELLS [J].

BUSSON, P ;

ZHANG, Q ;

GUILLON, JM ;

GREGORY, CD ;

YOUNG, LS ;

CLAUSSE, B ;

LIPINSKI, M ;

RICKINSON, AB ;

TURSZ, T .

INTERNATIONAL JOURNAL OF CANCER, 1992, 50 (06) :863-867

[8] Direct visualization of antigen-specific CD8+ T cells during the primary immune response to Epstein-Barr virus in vivo [J].

Callan, MFC ;

Tan, L ;

Annels, N ;

Ogg, GS ;

Wilson, JDK ;

O'Callaghan, CA ;

Steven, N ;

McMichael, AJ ;

Rickinson, AB .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (09) :1395-1402

[9]

*CENTR AN COMM, 1991, DAT BOOK 11 INT HIST, V2, P807

[10] IMPAIRED GENERAL CELL-MEDIATED IMMUNE FUNCTIONS INVIVO AND INVITRO IN PATIENTS WITH NASOPHARYNGEAL CARCINOMA [J].

CHAN, SH ;

CHEW, TS ;

GOH, EH ;

SIMONS, MJ ;

SHANMUGARATNAM, K .

INTERNATIONAL JOURNAL OF CANCER, 1976, 18 (02) :139-144

← 1 2 3 4 5 6 7 →