Allelic variation in srtAs of Streptococcus suis strains

被引：13

作者：

Osaki, M ^{[1
]}

Takamatsu, D ^{[1
]}

Shimoji, Y ^{[1
]}

Sekizaki, T ^{[1
]}

机构：

[1] Natl Inst Anim Hlth, Mol Bacteriol Sect, Tsukuba, Ibaraki 3050856, Japan

来源：

FEMS MICROBIOLOGY LETTERS | 2003年 / 219卷 / 02期

关键词：

cell wall protein; sortase; allelic variation; Streptococcus suis;

D O I：

10.1016/S0378-1097(03)00058-2

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Streptococcus suis NCTC10234 possesses five srtA homologs: srtA encodes sortase, which anchors surface proteins with an LPXTG motif to the cell wall, while the functions of the other four homologs (the srtBCD cluster and srtE) remain unknown. The genetic organization of the srtA region was found to be conserved in the 59 S. suis strains examined in this study. Although the srtAs in three of these strains showed strong sequence divergence, their functions were verified to be overlapping by genetic complementation, indicating the functional conservation of srtAs during the evolution of these strains. These results indicate the importance of an srtA-mediated cell wall sorting system for displaying proteins on the surface of S. suis. (C) 2003 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：195 / 201

页数：7

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