Differential effects of stereochemistry and C-4 substituents on the enantioselectivity of PLE and PPL catalysed hydrolysis of 3,4-disubstituted beta-lactams

被引：22

作者：

Basak, A

Mahato, T

Bhattacharya, G

Mukherjee, B

机构：

[1] Department of Chemistry, Indian Institute of Technology

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 04期

关键词：

D O I：

10.1016/S0040-4039(96)02381-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pig Liver Esterase (PLE) and Pig Pancreas Lipase (PPL) catalysed hydrolysis of (+/-)trans-3-carbethoxy and (+/-) cis-3-acetoxymethyl 4-substituted beta-lactams revealed interesting dependence on C-3, C-4 stereochemistry and nature of C-4 substituents. (C) 1997, Elsevier Science Ltd. All rights reserved.

引用

页码：643 / 646

页数：4

共 13 条

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