Elucidating DNA damage and repair processes by independently generating reactive and metastable intermediates

被引：66

作者：

Greenberg, Marc M. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Chem, Baltimore, MD 21218 USA

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2007年 / 5卷 / 01期

关键词：

D O I：

10.1039/b612729k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

DNA damage is a double-edged sword. The modi. cations produced in the biopolymer are associated with aging, and give rise to a variety of diseases, including cancer. DNA is also the target of anti-tumor agents and the most generally used nonsurgical treatment of cancer, ionizing radiation. Agents that damage DNA produce a variety of radicals. Elucidating the chemistry of individual DNA radicals is challenging due to the availability of multiple reactive pathways and complexities inherent with carrying out mechanistic studies on a heterogeneous polymer. The ability to independently generate radicals and their metastable products at defined sites in DNA has greatly facilitated understanding this biologically important chemistry.

引用

页码：18 / 30

页数：13

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