Acetylcholine-induced relaxation of rat aorta is greatest during estrus in the sexual cycle

被引：4

作者：

Honda, H

Ishihara, H

Takei, M

Kogo, H

机构：

[1] Department of Pharmacology, Tokyo Univ. of Pharm. and Life Sci., Hachioji, Tokyo 193-03, 1432-1, Horinouchi

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1997年 / 74卷 / 01期

关键词：

sexual cycle; nitric oxide; aorta;

D O I：

10.1254/jjp.74.113

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Acetylcholine (ACh)-induced relaxation in the aortae precontracted with norepinephrine was significantly enhanced in the aortae from estrus (E) rats, compared with that in those from metestrus (D-1), diestrus (D-2) and proestrus (PE) rats. N-G-Nitro-L-arginine methyl ester (L-NAME) inhibited the endothelium-dependent relaxation in E rats. These results suggest that there is a difference in ACh-induced relaxation of the thoracic aorta during the sexual cycle of rats, and the relaxation is greatest in E of the sexual cycle; this may be due to a difference in nitric oxide synthesis in the endothelium in the sexual cycle.

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收藏

页码：113 / 115

页数：3

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