Regulation of histone methylation by demethylimination and demethylation

被引:665
作者
Klose, Robert J. [1 ]
Yi Zhang [1 ]
机构
[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Biochem & Biophys, Howard Hughes Med Inst, Chapel Hill, NC 27599 USA
基金
美国国家卫生研究院; 加拿大健康研究院;
关键词
D O I
10.1038/nrm2143
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Histone methylation has important roles in regulating transcription, genome integrity and epigenetic inheritance. Historically, methylated histone arginine and lysine residues have been considered static modifications because of the low levels of methyl-group turnover in chromatin. The recent identification of enzymes that antagonize or remove histone methylation has changed this view and now the dynamic nature of these modifications is being appreciated. Here, we examine the enzymatic and structural basis for the mechanisms that these enzymes use to counteract histone methylation and provide insights into their substrate specificity and biological function.
引用
收藏
页码:307 / 318
页数:12
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