A guanylurea-functionalized conjugated polymer enables RNA interference in ex vivo human airway epithelium

被引：16

作者：

Ahmed, Md Salauddin ^{[1
]}

Dutta, Rajib Kumar ^{[2
]}

Manandhar, Prakash ^{[1
]}

Li, Xuerong ^{[1
]}

Torabi, Hooman ^{[1
]}

Barrios, Alfonso ^{[1
]}

Wang, Ping ^{[3
]}

Chinnapaiyan, Srinivasan ^{[2
]}

Unwalla, Hoshang Jehangir ^{[2
]}

Moon, Joong Ho ^{[1
]}

机构：

[1] Florida Int Univ, Biomol Sci Inst, Dept Chem & Biochem, 11200 SW 8th St, Miami, FL 33199 USA

[2] Florida Int Univ, Dept Immunol & Nanomed, 11200 SW 8th St, Miami, FL 33199 USA

[3] Florida Int Univ, Dept Elect Engn, 11200 SW 8th St, Miami, FL 33199 USA

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 54期

关键词：

DELIVERY; NANOPARTICLES; THERAPY;

D O I：

10.1039/c9cc02856k

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

We demonstrate a successful target gene knockdown in ex vivo normal human bronchial epithelium (NHBE) cells covered with mucus layers using the guanylurea functionalization technique modulating the chemical environment at the positive charge of a gene carrier.

引用

收藏

页码：7804 / 7807

页数：4

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