The comparison of in the vitro effect of imipenem or meropenem combined with ciprofloxacin or levofloxacin against multidrug-resistant Pseudomonas aeruginosa strains

被引：19

作者：

Erdem, I

Kaynar-Tascioglu, J

Kaya, B

Goktas, P

机构：

[1] Haydarpasa Numune Training & Res Hosp, Clin Infect Dis & Clin Microbiol, Istanbul, Turkey

[2] Haydarpasa Numune Training & Res Hosp, Lab Microbiol & Clin Microbiol, Istanbul, Turkey

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2002年 / 20卷 / 05期

关键词：

Pseudomonas aeruginosa; antimicrobial combinations; imipenem; meropenem; ciprofloxacin; levofloxacin;

D O I：

10.1016/S0924-8579(02)00192-9

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

This study evaluated the in vitro effects of the combination of a carbapenem (imipenem or meropenem) with a quinolone (ciprofloxacin or levofloxacin) using a microbroth dilution chequerboard technique and multidrug-resistant Pseudomonas aeruginosa strains. The ciprofloxacin and meropenem combination was only synergistic against 2 strains (6.2%) and ciprofloxacin and imipenem against 1 strain (3.1%). Levofloxacin and imipenem or meropenem were not synergistic for against any strain. None of the combinations showed an antagonistic effect. (C) 2002 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.

引用

页码：384 / 386

页数：3