Apolipoprotein C-III gene variation and dyslipidaemia

被引：53

作者：

Talmud, PJ

Humphries, SE

机构：

[1] Division of Cardiovascular Genetics, Department of Medicine, Univ. College London Medical School

[2] Division of Cardiovascular Genetics, Dept. Medicine, Univ. College London Medical School, London WC1E 6JJ

来源：

CURRENT OPINION IN LIPIDOLOGY | 1997年 / 8卷 / 03期

关键词：

D O I：

10.1097/00041433-199706000-00005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Within the apolipoprotein A-I-C-III-A-IV gene cluster, the Sstl polymorphism in the 3' untranslated region of the apolipoprotein C-III gene is the variant site most consistently and strongly associated with raised plasma triglyceride levels and coronary artery disease, To date the molecular mechanisms that underlie this effect have not been fully identified and variation within the insulin-responsive element of the apolipoprotein C-III proximal promoter cannot entirely explain the Sstl effect.

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页码：154 / 158

页数：5

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