Electrospinning of polysaccharides for regenerative medicine

被引：486

作者：

Lee, Kuen Yong ^{[2
]}

Jeong, Lim ^{[1
]}

Kang, Yun Ok ^{[1
]}

Lee, Seung Jin ^{[3
]}

Park, Won Ho ^{[1
]}

机构：

[1] Chungnam Natl Univ, Dept Adv Organ Mat & Text Syst Engn, Taejon 305764, South Korea

[2] Hanyang Univ, Dept Bioengn, Seoul 133791, South Korea

[3] Ewha Womans Univ, Coll Pharm, Seoul 120750, South Korea

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2009年 / 61卷 / 12期

关键词：

Polysaccharide; Electrospinning; Nanofiber; Regenerative medicine; CELLULOSE-ACETATE FIBERS; NORMAL HUMAN KERATINOCYTES; NANOFIBROUS SCAFFOLDS; CHITOSAN NANOFIBERS; IN-VITRO; RELEASE CHARACTERISTICS; QUATERNIZED CHITOSAN; SODIUM ALGINATE; SOLVENT SYSTEM; ACETIC-ACID;

D O I：

10.1016/j.addr.2009.07.006

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Electrospinning techniques enable the production of continuous fibers with dimensions on the scale of nanometers from a wide range of natural and synthetic polymers. The number of recent studies regarding electrospun polysaccharides and their derivatives, which are potentially useful for regenerative medicine, is increasing dramatically. However, difficulties regarding the processibility of the polysaccharides (e.g., poor solubility and high surface tension) have limited their application. In this review, we summarize the characteristics of various polysaccharides such as alginate, cellulose, chitin, chitosan, hyaluronic acid, starch, dextran, and heparin, which are either currently being used or have potential to be used for electrospinning. The recent progress of nanofiber matrices electrospun from polysaccharides and their biomedical applications in tissue engineering, wound dressings, drug delivery, and enzyme immobilization are discussed. (c) 2009 Elsevier B.V. All rights reserved.

引用

页码：1020 / 1032

页数：13

共 141 条

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