Local radiofrequency-induced hyperthermia using CuNi nanoparticles with therapeutically suitable Curie temperature

被引:53
作者
Kuznetsov, Anatoly A.
Leontiev, Vladimir G.
Brukvin, Vladimir A.
Vorozhtsov, Georgy N.
Kogan, Boris Ya.
Shlyakhtin, Oleg A.
Yunin, Alexander M.
Tsybin, Oleg I.
Kuznetsov, Oleg A.
机构
[1] Russian Acad Sci, Inst Biochem Phys, Moscow 119991, Russia
[2] Russian Acad Sci, Inst Met, Moscow 119991, Russia
[3] NIOPIK Organ Intermediates & Dyes Inst, Moscow 103787, Russia
[4] Russian Acad Sci, Inst Chem Phys, Moscow 119991, Russia
关键词
magnetic fluid hyperthermia; radiofrequency heating; Curie temperature; temperature control by parametric feedback; nanoparticle; copper-nickel alloy; cancer treatment; THERAPY;
D O I
10.1016/j.jmmm.2006.11.199
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Copper-nickel (CuNi) alloy nanoparticles with Curie temperatures (T-c) from 40 to 60 degrees C were synthesized by several techniques. Varying the synthesis parameters and post-treatment, as well as separations by size and T-c, allow producing mediator nanoparticles for magnetic fluid hyperthermia with parametric feedback temperature control with desired parameters. In vitro and in vivo animal experiments have demonstrated the feasibility of the temperature-controlled heating of the tissue, laden with the particles, by an external alternating magnetic field. (C) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码:197 / 203
页数:7
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