Straightforward syntheses of furanomycin derivatives and their biological evaluation

被引：26

作者：

Kazmaier, U

Pähler, S

Endermann, R

Häbich, D

Kroll, HP

Riedl, B

机构：

[1] Univ Saarland, Inst Organ Chem, D-66123 Saarbrucken, Germany

[2] Bayer AG, Pharma Res, D-42096 Wuppertal, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2002年 / 10卷 / 12期

关键词：

D O I：

10.1016/S0968-0896(02)00317-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several types of furanomycin analogues were synthesized and investigated with respect to their antibacterial activity. Two different synthetic pathways were developed, based on aldol reactions/ring closing metathesis and an ester enolate Claisen rearrangement. Only the natural product and its desmethyl derivative showed antibacterial activity, pointing towards a narrow structure-activity relationship. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：3905 / 3913

页数：9

共 25 条

[1] ESTER-ENOLATE CLAISEN REARRANGEMENT OF ALPHA-AMINO-ACID DERIVATIVES [J].