Cerebral blood flow in ischemic vascular dementia and Alzheimer's disease, measured by arterial spin-labeling magnetic resonance imaging

被引：168

作者：

Schuff, Norbert ^{[1
,2
]}

Matsumoto, Shinji ^{[3
]}

Kmiecik, Joseph

Studholme, Colin ^{[1
,2
]}

Du, Antao ^{[1
]}

Ezekiel, Frank ^{[1
,2
]}

Miller, Bruce L. ^{[4
]}

Kramer, Joel H. ^{[5
]}

Jagust, William J. ^{[6
,7
]}

Chui, Helen C. ^{[8
]}

Weiner, Michael W. ^{[1
,2
,9
]}

机构：

[1] Univ Calif San Francisco, Dept Vet Affairs Med Ctr, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA

[3] Fed Patent Off Japan, Tokyo, Japan

[4] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

[5] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA

[6] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA

[7] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA

[8] Univ So Calif, Dept Neurol, Los Angeles, CA USA

[9] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

来源：

ALZHEIMERS & DEMENTIA | 2009年 / 5卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Magnetic resonance imaging; Cerebral blood flow; Subcortical ischemic vascular dementia; Alzheimer's disease; Cortex; Segmentation; White-matter lesions; FRONTAL-LOBE HYPOMETABOLISM; WHITE-MATTER LESIONS; EMISSION-TOMOGRAPHY; BRAIN; SPECT; MRI; HYPOPERFUSION; DIAGNOSIS; SEVERITY; PATTERNS;

D O I：

10.1016/j.jalz.2009.04.1233

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Our objectives were to compare the effects of subcortical ischemic vascular dementia (SIVD) and Alzheimer's disease (AD) on cerebral blood flow (CBF), and then to analyze the relationship between CBF and subcortical vascular disease, measured as volume of white-matter lesions (WMLs). Methods: Eight mildly demented patients with SIVD (mean +/- SD; aged 77 +/- 8 years; Mini-Mental State Examination score 26 3 years) and 14 patients with AD were compared with 18 cognitively normal elderly subjects. All subjects had CBF measured using arterial spin-labeling magnetic resonance imaging, and brain volumes were assessed using structural magnetic resonance imaging. Results: AD and SIVD showed marked CBF reductions in the frontal (P = 0.001) and parietal (P = 0.001) cortices. In SIVD, increased subcortical WMLs were associated with reduced CBF in the frontal cortex (P = 0.04), in addition to cortical atrophy (frontal, P = 0.05; parietal, P = 0.03). Conclusions: Subcortical vascular disease is associated with reduced CBF in the cortex, irrespective of brain atrophy. (C) 2009 The Alzheimer's Association. All rights reserved.

引用

页码：454 / 462

页数：9

共 49 条

[1]

Alsop DC, 2000, ANN NEUROL, V47, P93, DOI 10.1002/1531-8249(200001)47:1<93::AID-ANA15>3.0.CO

[2]

2-8

[3]

CHUI H, 2002, EVIDENCE BASED DEMEN, P106

[4]

Chui H., 2001, CLIN CORNERSTONE, V3, P40

[5] CRITERIA FOR THE DIAGNOSIS OF ISCHEMIC VASCULAR DEMENTIA PROPOSED BY THE STATE OF CALIFORNIA ALZHEIMERS-DISEASE-DIAGNOSTIC-AND-TREATMENT-CENTERS [J].

CHUI, HC ;

VICTOROFF, JI ;

MARGOLIN, D ;

JAGUST, W ;

SHANKLE, R ;

KATZMAN, R .

NEUROLOGY, 1992, 42 (03) :473-480

[6] Cognitive impact of subcortical vascular and Alzheimer's disease pathology [J].

Chui, Helena C. ;

Zarow, Chris ;

Mack, Wendy J. ;

Ellis, William G. ;

Zheng, Ling ;

Jagust, William J. ;

Mungas, Dan ;

Reed, Bruce R. ;

Kramer, Joel H. ;

DeCarli, Charles C. ;

Weiner, Michael W. ;

Vinters, Harry V. .

ANNALS OF NEUROLOGY, 2006, 60 (06) :677-687

[7] CEREBRAL BLOOD-FLOW IN SEVERITY-MATCHED ALZHEIMER AND MULTIINFARCT PATIENTS [J].

DEUTSCH, G ;

TWEEDY, JR .

NEUROLOGY, 1987, 37 (03) :431-438

[8] Hypoperfusion in frontotemporal dementia and Alzheimer disease by arterial spin labeling MRI [J].

Du, A. T. ;

Jahng, G. H. ;

Hayasaka, S. ;

Kramer, J. H. ;

Rosen, H. J. ;

Gorno-Tempini, M. L. ;

Rankin, K. P. ;

Miller, B. L. ;

Weiner, M. W. ;

Schuff, N. .

NEUROLOGY, 2006, 67 (07) :1215-1220

[9] EPISTAR MRI: Multislice mapping of cerebral blood flow [J].

Edelman, RR ;

Chen, G .

MAGNETIC RESONANCE IN MEDICINE, 1998, 40 (06) :800-805

[10] Hippocampal and cortical atrophy predict dementia in subcortical ischemic vascular disease [J].

Fein, G ;

Di Sclafani, V ;

Tanabe, J ;

Cardenas, V ;

Weiner, MW ;

Jagust, WJ ;

Reed, BR ;

Norman, D ;

Schuff, N ;

Kusdra, L ;

Greenfield, T ;

Chui, H .

NEUROLOGY, 2000, 55 (11) :1626-1635

← 1 2 3 4 5 →