Pathogenesis and Transmission of Swine-Origin 2009 A(H1N1) Influenza Virus in Ferrets

被引：496

作者：

Munster, Vincent J. ^{[1
,2
]}

de Wit, Emmie ^{[1
,2
]}

van den Brand, Judith M. A. ^{[1
,2
]}

Herfst, Sander ^{[1
,2
]}

Schrauwen, Eefje J. A. ^{[1
,2
]}

Bestebroer, Theo M. ^{[1
,2
]}

van de Vijver, David ^{[1
,2
]}

Boucher, Charles A. ^{[1
,2
]}

Koopmans, Marion ^{[1
,2
,3
]}

Rimmelzwaan, Guus F. ^{[1
,2
]}

Kuiken, Thijs ^{[1
,2
]}

Osterhaus, Albert D. M. E. ^{[1
,2
]}

Fouchier, Ron A. M. ^{[1
,2
]}

机构：

[1] Erasmus MC, Natl Influenza Ctr, NL-3015 GE Rotterdam, Netherlands

[2] Erasmus MC, Dept Virol, NL-3015 GE Rotterdam, Netherlands

[3] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands

来源：

SCIENCE | 2009年 / 325卷 / 5939期

关键词：

H5N1; VIRUSES; A VIRUS; HUMANS; VIRULENCE; MAMMALS;

D O I：

10.1126/science.1177127

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The swine-origin A(H1N1) influenza virus that has emerged in humans in early 2009 has raised concerns about pandemic developments. In a ferret pathogenesis and transmission model, the 2009 A(H1N1) influenza virus was found to be more pathogenic than a seasonal A(H1N1) virus, with more extensive virus replication occurring in the respiratory tract. Replication of seasonal A(H1N1) virus was confined to the nasal cavity of ferrets, but the 2009 A(H1N1) influenza virus also replicated in the trachea, bronchi, and bronchioles. Virus shedding was more abundant from the upper respiratory tract for 2009 A(H1N1) influenza virus as compared with seasonal virus, and transmission via aerosol or respiratory droplets was equally efficient. These data suggest that the 2009 A(H1N1) influenza virus has the ability to persist in the human population, potentially with more severe clinical consequences.

引用

页码：481 / 483

页数：3

共 18 条

[1] Pathogenesis of avian influenza (H7) virus infection in mice and ferrets: Enhanced virulence of Eurasian H7N7 viruses isolated from humans
Belser, Jessica A.
Lu, Xuihua
Maines, Taronna R.
Smith, Catherine
Li, Yan
Donis, Ruben O.
Katz, Jacqueline M.
Tumpey, Terrence M.
[J]. JOURNAL OF VIROLOGY, 2007, 81 (20) : 11139 - 11147
[2] The origins of pandemic influenza - Lessons from the 1918 virus
Belshe, RB
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (21) : 2209 - 2211
[3] Pandemic Potential of a Strain of Influenza A (H1N1): Early Findings
Fraser, Christophe
Donnelly, Christl A.
Cauchemez, Simon
Hanage, William P.
Van Kerkhove, Maria D.
Hollingsworth, T. Deirdre
Griffin, Jamie
Baggaley, Rebecca F.
Jenkins, Helen E.
Lyons, Emily J.
Jombart, Thibaut
Hinsley, Wes R.
Grassly, Nicholas C.
Balloux, Francois
Ghani, Azra C.
Ferguson, Neil M.
Rambaut, Andrew
Pybus, Oliver G.
Lopez-Gatell, Hugo
Alpuche-Aranda, Celia M.
Bojorquez Chapela, Ietza
Palacios Zavala, Ethel
Espejo Guevara, Dulce Ma.
Checchi, Francesco
Garcia, Erika
Hugonnet, Stephane
Roth, Cathy
[J]. SCIENCE, 2009, 324 (5934) : 1557 - 1561
[4] Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans
Garten, Rebecca J.
Davis, C. Todd
Russell, Colin A.
Shu, Bo
Lindstrom, Stephen
Balish, Amanda
Sessions, Wendy M.
Xu, Xiyan
Skepner, Eugene
Deyde, Varough
Okomo-Adhiambo, Margaret
Gubareva, Larisa
Barnes, John
Smith, Catherine B.
Emery, Shannon L.
Hillman, Michael J.
Rivailler, Pierre
Smagala, James
de Graaf, Miranda
Burke, David F.
Fouchier, Ron A. M.
Pappas, Claudia
Alpuche-Aranda, Celia M.
Lopez-Gatell, Hugo
Olivera, Hiram
Lopez, Irma
Myers, Christopher A.
Faix, Dennis
Blair, Patrick J.
Yu, Cindy
Keene, Kimberly M.
Dotson, P. David, Jr.
Boxrud, David
Sambol, Anthony R.
Abid, Syed H.
George, Kirsten St.
Bannerman, Tammy
Moore, Amanda L.
Stringer, David J.
Blevins, Patricia
Demmler-Harrison, Gail J.
Ginsberg, Michele
Kriner, Paula
Waterman, Steve
Smole, Sandra
Guevara, Hugo F.
Belongia, Edward A.
Clark, Patricia A.
Beatrice, Sara T.
Donis, Ruben
[J]. SCIENCE, 2009, 325 (5937) : 197 - 201
[5] Lethality to ferrets of H5N1 influenza viruses isolated from humans and poultry in 2004
Govorkova, EA
Rehg, JE
Krauss, S
Yen, HL
Guan, Y
Peiris, M
Nguyen, TD
Hanh, TH
Puthavathana, P
Long, HT
Buranathai, C
Lim, W
Webster, RG
Hoffmann, E
[J]. JOURNAL OF VIROLOGY, 2005, 79 (04) : 2191 - 2198
[6] Lackenby A, 2008, EUROSURVEILLANCE, V13, P113
[7] The ferret: An animal model to study influenza virus
Maher, JA
DeStefano, J
[J]. LAB ANIMAL, 2004, 33 (09) : 50 - +
[8] Avian influenza (H5N1) viruses isolated from humans in Asia in 2004 exhibit increased virulence in mammals
Maines, TR
Lu, XH
Erb, SM
Edwards, L
Guarner, J
Greer, PW
Nguyen, DC
Szretter, KJ
Chen, LM
Thawatsupha, P
Chittaganpitch, M
Waicharoen, S
Nguyen, DT
Nguyen, T
Nguyen, HHT
Kim, JH
Hoang, LT
Kang, C
Phuong, LS
Lim, W
Zaki, S
Donis, RO
Cox, NJ
Katz, JM
Tumpey, TM
[J]. JOURNAL OF VIROLOGY, 2005, 79 (18) : 11788 - 11800
[9] Epidemics of two Victoria and Yamagata influenza B lineages in Yamagata, Japan
Mizuta, K
Itagaki, T
Abiko, C
Murata, T
Takahashi, T
Murayama, S
[J]. EPIDEMIOLOGY AND INFECTION, 2004, 132 (04) : 721 - 726
[10] Multiple reassortment events in the evolutionary history of H1N1 influenza A virus since 1918
Nelson, Martha I.
Viboud, Cecile
Simonsen, Lone
Bennett, Ryan T.
Griesemer, Sara B.
George, Kirsten St.
Taylor, Jill
Spiro, David J.
Sengamalay, Naomi A.
Ghedin, Elodie
Taubenberger, Jeffery K.
Holmes, Edward C.
[J]. PLOS PATHOGENS, 2008, 4 (02)

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