Relationship between steroid hormone contraceptives and HPV, cervical intraepithelial neoplasia and cervical carcinoma

被引:71
作者
de Villiers, EM [1 ]
机构
[1] Deutsch Krebsforschungszentrum, Div Characterizat Tumor Viruses, D-69120 Heidelberg, Germany
关键词
HPV; hormone; cervical intraepithelial neoplasia; cervical cancer;
D O I
10.1002/ijc.10868
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Available data demonstrate an increase in the transcription of high-risk papillomaviruses by the 16alpha-hydroxylation of estrogens, which is in line with the epidemiologic data showing an increased cervical carcinogenesis risk for long-term contraceptive-using, HPV-infected women. No evidence exists for an increase in HPV-negative contraceptive users. (C) 2002 Wiley-Liss, Inc.
引用
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页码:705 / 708
页数:4
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