Polyoma virus middle T antigen and its role in identifying cancer-related molecules

被引：89

作者：

Dilworth, SM ^{[1
]}

机构：

[1] Hammersmith Hosp, Imperial Coll, Fac Med, Dept Metab Med, London W12 0NN, England

来源：

NATURE REVIEWS CANCER | 2002年 / 2卷 / 12期

关键词：

D O I：

10.1038/nrc946

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Most cancer researchers take for granted some of the basic concepts about the molecular changes that underlie tumorigenesis. These include the principles that tyrosine kinases and the phosphorylation of phosphatidylinositol by phosphatidylinositol 3-kinases are important in the signalling pathways that control proliferation and apoptosis, and hence cancer formation. However, how many know that a small DNA mouse virus was crucial in establishing both of these tenets?

引用

页码：951 / 956

页数：6

共 65 条

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