Growth signaling: TSC takes its place

被引：64

作者：

Marygold, SJ ^{[1
]}

Leevers, SJ ^{[1
]}

机构：

[1] Canc Res UK London Res Inst, Growth Regulat Lab, London WC2A 3PX, England

来源：

CURRENT BIOLOGY | 2002年 / 12卷 / 22期

关键词：

D O I：

10.1016/S0960-9822(02)01294-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The protein products of the tumor suppressor genes tuberous sclerosis complex 1 and 2 form a protein complex, TSC1-TSC2, that inhibits growth. Several new studies suggest that TSC1-TSC2 does this by inhibiting TOR and S6 kinase, and that PI 3-kinase-Akt signaling relieves this inhibition.

引用

页码：R785 / R787

页数：3

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