Fatty acid amide hydrolase expression in rat choroid plexus:: possible role in regulation of the sleep-inducing action of oleamide

被引:25
作者
Egertová, M
Cravatt, BF
Elphick, MR
机构
[1] Univ London Queen Mary & Westfield Coll, Sch Biol Sci, London E1 4NS, England
[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
[3] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA
基金
英国惠康基金;
关键词
fatty acid amide hydrolase; choroid plexus; cerebrospinal fluid; oleamide; sleep; anandamide; cannabinoid;
D O I
10.1016/S0304-3940(00)00841-7
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The enzyme fatty acid amide hydrolase (FAAH) catalyses hydrolysis of oleamide, a sleep-inducing lipid whose concentration in the cerebrospinal fluid (CSF) is elevated in sleep-deprived mammals. Previous studies have reported expression of FAAH by distinct populations of neurons in the rat brain. Here we demonstrate using immunocytochemical methods that FAAH is also expressed by non-neuronal epithelial cells of the rat choroid plexus. The choroid plexus is formed by invaginations of the pia mater into the ventricle cavities of the brain and an important function of the choroidal epithelium is to regulate production and composition of CSF. Therefore, the role of FAAH in epithelial cells of the choroid plexus may be to control the concentration of oleamide in the CSF and as such FAAH may exert an important regulatory role in shaping the duration and magnitude of the sleep-inducing effect of endogenously or exogenously derived oleamide. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:13 / 16
页数:4
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