Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork

被引：427

作者：

Hertweck, Christian

Luzhetskyy, Andriy

Rebets, Yuri

Bechthold, Andreas

机构：

[1] Univ Freiburg, Inst Pharmazeut Wissensch Pharmazeut Biol & Biote, D-79104 Freiburg, Germany

[2] HKI, Leibniz Inst Nat Prod Res & Infect Biol, D-07745 Jena, Germany

来源：

NATURAL PRODUCT REPORTS | 2007年 / 24卷 / 01期

关键词：

D O I：

10.1039/b507395m

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review covers advances in understanding of the biosynthesis of polyketides produced by type II PKS systems at the genetic, biochemical and structural levels.

引用

页码：162 / 190

页数：29

共 276 条

[11]

Baeyer A., 1899, Ber. Dtsch. Chem. Ges., V32, P3625, DOI 10.1002/cber.189903203151

[12] ANTI-TUMOR AGENTS FROM STREPTOMYCES-ANANDII - GILVOCARCINS-V, GILVOCARCINS-M AND GILVOCARCINS-E [J].

BALITZ, DM ;

OHERRON, FA ;

BUSH, J ;

VYAS, DM ;

NETTLETON, DE ;

GRULICH, RE ;

BRADNER, WT ;

DOYLE, TW ;

ARNOLD, E ;

CLARDY, J .

JOURNAL OF ANTIBIOTICS, 1981, 34 (12) :1544-1555

[13] The Streptomyces peucetius dpsC gene determines the choice of starter unit in biosynthesis of the daunorubicin polyketide [J].

Bao, WL ;

Sheldon, PJ ;

Wendt-Pienkowsi, E ;

Hutchinson, CR .

JOURNAL OF BACTERIOLOGY, 1999, 181 (15) :4690-4695

[14] Reconstitution of the iterative type II polyketide synthase for tetracenomycin F2 biosynthesis [J].

Bao, WL ;

Wendt-Pienkowski, E ;

Hutchinson, CR .

BIOCHEMISTRY, 1998, 37 (22) :8132-8138

[15] Purification and properties of the Streptomyces peucetius DpsC β-ketoacyl:acyl carrier protein synthase III that specifies the propionate-starter unit for type II polyketide biosynthesis [J].

Bao, WL ;

Sheldon, PJ ;

Hutchinson, CR .

BIOCHEMISTRY, 1999, 38 (30) :9752-9757

[16] BIOSYNTHESIS OF ANTHRAQUINONES BY INTERSPECIES CLONING OF ACTINORHODIN BIOSYNTHESIS GENES IN STREPTOMYCETES - CLARIFICATION OF ACTINORHODIN GENE FUNCTIONS [J].

BARTEL, PL ;

ZHU, CB ;

LAMPEL, JS ;

DOSCH, DC ;

CONNORS, NC ;

STROHL, WR ;

BEALE, JM ;

FLOSS, HG .

JOURNAL OF BACTERIOLOGY, 1990, 172 (09) :4816-4826

[17]

Batist G, 2001, Cancer Chemother Biol Response Modif, V19, P47

[18] Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2) [J].

Bentley, SD ;

Chater, KF ;

Cerdeño-Tárraga, AM ;

Challis, GL ;

Thomson, NR ;

James, KD ;

Harris, DE ;

Quail, MA ;

Kieser, H ;

Harper, D ;

Bateman, A ;

Brown, S ;

Chandra, G ;

Chen, CW ;

Collins, M ;

Cronin, A ;

Fraser, A ;

Goble, A ;

Hidalgo, J ;

Hornsby, T ;

Howarth, S ;

Huang, CH ;

Kieser, T ;

Larke, L ;

Murphy, L ;

Oliver, K ;

O'Neil, S ;

Rabbinowitsch, E ;

Rajandream, MA ;

Rutherford, K ;

Rutter, S ;

Seeger, K ;

Saunders, D ;

Sharp, S ;

Squares, R ;

Squares, S ;

Taylor, K ;

Warren, T ;

Wietzorrek, A ;

Woodward, J ;

Barrell, BG ;

Parkhill, J ;

Hopwood, DA .

NATURE, 2002, 417 (6885) :141-147

[19] The regulation of antibiotic production in Streptomyces coelicolor A3(2) [J].

Bibb, M .

MICROBIOLOGY-SGM, 1996, 142 :1335-1344

[20] σBldN, an extracytoplasmic function RNA polymerase sigma factor required for aerial mycelium formation in Streptomyces coelicolor A3(2) [J].

Bibb, MJ ;

Molle, V ;

Buttner, MJ .

JOURNAL OF BACTERIOLOGY, 2000, 182 (16) :4606-4616

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