Activity-guided isolation of constituents of Tephrosia purpurea with the potential to induce the Phase II enzyme, quinone reductase

被引：84

作者：

Chang, LC ^{[1
]}

Gerhauser, C ^{[1
]}

Song, L ^{[1
]}

Farnsworth, NR ^{[1
]}

Pezzuto, JM ^{[1
]}

Kinghorn, AD ^{[1
]}

机构：

[1] UNIV ILLINOIS,COLL PHARM,DEPT MED CHEM & PHARMACOGNOSY,PROGRAM COLLABORAT RES PHARMACEUT SCI,CHICAGO,IL 60612

来源：

JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 09期

关键词：

D O I：

10.1021/np970236p

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

An isoflavone, 7,4'-dihydroxy-3',5'-dimethoxyisoflavone (i), and a chalcone, (+)-tephropurpurin (2), both novel compounds, as well as six constituents of known structure, (+)-purpurin (3), pongamol (4), lanceolatin B (5), (-)-maackiain (6), (-)-3-hydroxy-4-methoxy-8,9-methylene-dioxypterocarpan (7), and (-)-medicarpin (8), were obtained as active compounds from Tephrosia purpurea, using a bioassay based on the induction of quinone reductase (QR) activity with cultured Hepa 1c1c7 mouse hepatoma cells. Additionally, three inactive compounds of known structure, 3'-methoxydaidzein, desmoxyphyllin B, and 3,9-dihydroxy-8-methoxycoumestan, were isolated and identified. The structure elucidation of compounds 1 and 2 was carried out by spectral data interpretation.

引用

页码：869 / 873

页数：5

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[11] COUMARONOCHROMONES FROM LEAVES OF DESMODIUM-OXYPHYLLUM [J].