Liver transplantation in HIV-HCV coinfected patients:: A case-control study

被引：32

作者：

Castells, Lluis

Escartin, Alfredo

Bilbao, Itxarone

Len, Oscar

Allende, Helena

Vargas, Victor

Ribera, Esteban

Lazaro, Jose-Luis

Bueno, Javier

Balsells, Joaquin

Esteban, Rafael

Pahissa, Albert

Margarit, Carlos

机构：

[1] Autonomous Univ Barcelona, Hosp Vall Hebron, Dept Internal Med, Liver Unit, E-08193 Barcelona, Spain

[2] Autonomous Univ Barcelona, Hosp Vall Hebron, Dept Surg, Liver Transplant Unit, E-08193 Barcelona, Spain

[3] Autonomous Univ Barcelona, Hosp Vall Hebron, Dept Infect Dis, E-08193 Barcelona, Spain

[4] Autonomous Univ Barcelona, Hosp Vall Hebron, Dept Pathol, E-08193 Barcelona, Spain

来源：

TRANSPLANTATION | 2007年 / 83卷 / 03期

关键词：

HIV infection; HCV infection; liver transplantation; HCV recurrence; HAART toxicity; antiviral treatment;

D O I：

10.1097/01.tp.0000251378.70853.90

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Liver transplantation (LT) for hepatitis C virus (HCV)-associated cirrhosis in human immunodeficiency virus (HIV)infected patients was compared with non-HIV patients. Nine patients with HIV-HCV coinfection were compared with patients transplanted before and after each HIV patient (control group). Immunosuppression consisted in tacrolimus with steroids or mycophenolate mofetil. Acute cellular rejection and three-year actuarial patient survival were respectively 44% and 87.5% in HIV group and 22% and 93.7% in the control group (P=NS). Acute hepatitis C virus occurred earlier (2.3 vs. 4.3 months) and was more cholestatic (mean bilirubin: 10.8 vs. 1.6 mg/dL) in the HIV group. Eight (100%) HIV and nine (64.3%) control patients received antiviral treatment with pegylated interferon and ribavirin. One patient (11.1%) of the control group and one patient (20%) of the HIV group presented a sustained virologic response (P=NS). Short-to midterm results of LT in HIV-HCV co-infected patients were excellent and similar to non-HIV patients.

引用

页码：354 / 358

页数：5

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