Vitamin D deficiency and type 2 diabetes

被引：88

作者：

Ozfirat, Zehra ^{[1
]}

Chowdhury, Tahseen A. ^{[1
]}

机构：

[1] Barts & London Queen Marys Sch Med & Dent, Dept Diabet & Metab, London, England

来源：

POSTGRADUATE MEDICAL JOURNAL | 2010年 / 86卷 / 1011期

关键词：

PROLIFERATOR-ACTIVATED-RECEPTOR; CALCIUM-BINDING PROTEIN; INSULIN-SECRETION; GLUCOSE-TOLERANCE; D SUPPLEMENTATION; SERUM; 25-HYDROXYVITAMIN-D; 1,25-DIHYDROXYVITAMIN D-3; GLUCAGON-SECRETION; METABOLIC SYNDROME; PHYSICAL-ACTIVITY;

D O I：

10.1136/pgmj.2009.078626

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type 2 diabetes is a major public health problem, accounting for significant premature mortality and morbidity. The growth in prevalence of the condition appears to be closely linked with obesity. Over the last 5 years, a number of large observational studies have suggested an association between the onset of type 2 diabetes and Vitamin D deficiency. Vitamin D has important effects on insulin action, and may impact on a number of pathways which may be of importance in the development of type 2 diabetes. This article reviews the evidence linking Vitamin D deficiency in the pathogenesis of type 2 diabetes, and suggests areas for urgent further research to determine whether Vitamin D replacement has a role in the prevention of type 2 diabetes.

引用

页码：18 / 25

页数：8

共 75 条

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