Heparin: From the original ''soup'' to well-designed heparin mimetics

被引：15

作者：

Petitou, M ^{[1
]}

vanBoeckel, CAA ^{[1
]}

机构：

[1] ORGANON INT BV,SCI DEV GRP,NL-5340 BH OSS,NETHERLANDS

来源：

PURE AND APPLIED CHEMISTRY | 1997年 / 69卷 / 09期

关键词：

D O I：

10.1351/pac199769091839

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Since its introduction in 1937 heparinotherapy has improved consistently. In this article we describe the rationale behind the different steps of the evolution that, starting from a very impure polysaccharide mixture, ended in the proposal for development of pure synthetic antithrombotic oligosaccharides.

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页码：1839 / 1846

页数：8

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