BIOLOGICALLY-ACTIVE HEPARIN-LIKE FRAGMENTS WITH A NON-GLYCOSAMINO GLYCAN STRUCTURE .2. A TETRA-ORTHO-METHYLATED PENTASACCHARIDE WITH HIGH-AFFINITY FOR ANTITHROMBIN-III

被引:20
作者
BASTEN, J
JAURAND, G
OLDEHANTER, B
PETITOU, M
VANBOECKEL, CAA
机构
[1] SANOFI RECH,9 RUE PRESIDENT SALVADOR ALLENDE,F-94256 GENTILLY,FRANCE
[2] ORGANON INT BV,5340 BH OSS,NETHERLANDS
关键词
D O I
10.1016/S0960-894X(00)80584-3
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
To simplify the preparation of biologically active oligosaccharide analogues of glycosaminoglycan fragments we describe an approach where N-sulphates are replaced by O-sulphates and free hydroxyls are substituted by methyl groups. In this communication we report on the synthesis of a pentasaccharide in which hydroxyl groups of the non-reducing end disaccharide sub-region are methylated. The biological properties of this chemically modified analogue are fully preserved.
引用
收藏
页码:901 / 904
页数:4
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