Sources of urinary proteins and their analysis by urinary proteomics for the detection of biomarkers of disease

被引：58

作者：

Julian, Bruce A. ^{[1
]}

Suzuki, Hitoshi ^{[2
,3
]}

Suzuki, Yusuke ^{[3
]}

Tomino, Yasuhiko ^{[3
]}

Spasovski, Goce ^{[4
]}

Novak, Jan ^{[2
]}

机构：

[1] Univ Alabama Birmingham, Div Nephrol, Sch Med, Birmingham, AL 35294 USA

[2] Univ Alabama Birmingham, Dept Microbiol, Sch Med, Birmingham, AL 35294 USA

[3] Juntendo Univ, Sch Med, Dept Internal Med, Div Nephrol, Tokyo 113, Japan

[4] Univ Skopje, Fac Med, Dept Nephrol, Skopje, North Macedonia

来源：

PROTEOMICS CLINICAL APPLICATIONS | 2009年 / 3卷 / 09期

关键词：

Glomerular filtration; Nephron; Proteinuria; Renal tubule; ELECTRON-CAPTURE DISSOCIATION; RESOLUTION PROTEOME/PEPTIDOME ANALYSIS; INFRARED MULTIPHOTON DISSOCIATION; RESONANCE MASS-SPECTROMETRY; ABERRANT O-GLYCOSYLATION; PROXIMAL TUBULAR CELLS; CHRONIC KIDNEY-DISEASE; ALBUMIN EXCRETION RATE; RAT MESANGIAL CELLS; IGA NEPHROPATHY;

D O I：

10.1002/prca.200800243

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Renal disorders account for a substantial fraction of the budget for health care in many countries. Proteinuria is a frequent manifestation in afflicted patients, but the origin of the proteins varies based on the nature of the disorder. The emerging field of urinary proteomics has the potential to replace kidney biopsy as the diagnostic procedure of choice for patients with some glomerular forms of renal disease. To fully realize this potential, it is vital to understand the basis for the urinary excretion of protein in physiological and pathological conditions. In this review, we discuss the structure of the nephron, the functional unit of the kidney, and the process by which proteins/peptides enter the urine. We discuss several aspects of proteinuria that impact the proteomic analysis of urine of patients with renal diseases.

引用

页码：1029 / 1043

页数：15

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