Nucleotide sugar transporters of the golgi apparatus: From basic science to diseases

被引：72

作者：

Caffaro, Carolina E. ^{[1
]}

Hirschberg, Carlos B. ^{[1
]}

机构：

[1] Boston Univ, Dept Mol & Cell Biol, Goldman Sch Dent Med, Boston, MA 02118 USA

来源：

ACCOUNTS OF CHEMICAL RESEARCH | 2006年 / 39卷 / 11期

关键词：

D O I：

10.1021/ar0400239

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Approximately 80% of secreted and membrane proteins (40% of all proteins) of eukaryotes become covalently linked to sugars in the lumen of the Golgi apparatus, a cellular organelle that is part of the secretory system of all eukaryotes. The sugar donors are mostly nucleoside diphosphate sugars (nucleotide sugars) and must be translocated from the cytosol, their site of synthesis, across the Golgi apparatus membrane and into the lumen by specific transporters. These are hydrophobic, homodimeric proteins that span the membrane multiple times. Mutants of these proteins have developmental phenotypes including diseases in humans and cattle.

引用

页码：805 / 812

页数：8

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