Nucleotide sugar transporters of the golgi apparatus: From basic science to diseases

被引:72
作者
Caffaro, Carolina E. [1 ]
Hirschberg, Carlos B. [1 ]
机构
[1] Boston Univ, Dept Mol & Cell Biol, Goldman Sch Dent Med, Boston, MA 02118 USA
关键词
D O I
10.1021/ar0400239
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Approximately 80% of secreted and membrane proteins (40% of all proteins) of eukaryotes become covalently linked to sugars in the lumen of the Golgi apparatus, a cellular organelle that is part of the secretory system of all eukaryotes. The sugar donors are mostly nucleoside diphosphate sugars (nucleotide sugars) and must be translocated from the cytosol, their site of synthesis, across the Golgi apparatus membrane and into the lumen by specific transporters. These are hydrophobic, homodimeric proteins that span the membrane multiple times. Mutants of these proteins have developmental phenotypes including diseases in humans and cattle.
引用
收藏
页码:805 / 812
页数:8
相关论文
共 45 条
[21]   The Golgi GDPase of the fungal pathogen Candida albicans affects morphogenesis, glycosylation, and cell wall properties [J].
Herrero, AB ;
Uccelletti, D ;
Hirschberg, CB ;
Dominguez, A ;
Abeijon, C .
EUKARYOTIC CELL, 2002, 1 (03) :420-431
[22]  
Hirschberg CB, 2001, J CLIN INVEST, V108, P3
[23]   Transporters of nucleotide sugars, ATP, and nucleotide sulfate in the endoplasmic reticulum and Golgi apparatus [J].
Hirschberg, CB ;
Robbins, PW ;
Abeijon, C .
ANNUAL REVIEW OF BIOCHEMISTRY, 1998, 67 :49-69
[24]   Loss of srf-3-encoded nucleotide sugar transporter activity in Caenorhabditis elegans alters surface antigenicity and prevents bacterial adherence [J].
Höflich, J ;
Berninsone, P ;
Göbel, C ;
Gravato-Nobre, MJ ;
Libby, BJ ;
Darby, C ;
Politz, SM ;
Hodgkin, J ;
Hirschberg, CB ;
Baumeister, R .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (29) :30440-30448
[25]   The Leishmania GDP-mannose transporter is an autonomous, multi-specific, hexameric complex of LPG2 subunits [J].
Hong, KJ ;
Ma, DQ ;
Beverley, SM ;
Turco, SJ .
BIOCHEMISTRY, 2000, 39 (08) :2013-2022
[26]   The SQV-1 UDP-glucuronic acid decarboxylase and the SQV-7 nucleotide-sugar transporter may act in the Golgi apparatus to affect Caenorhabditis elegans vulval morphogenesis and embryonic development [J].
Hwang, HY ;
Horvitz, HR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (22) :14218-14223
[27]   Molecular physiology and pathology of the nucleotide sugar transporter family (SLC35) [J].
Ishida, N ;
Kawakita, M .
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2004, 447 (05) :768-775
[28]   Complementation cloning identifies CDG-IIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiency [J].
Lübke, T ;
Marquardt, T ;
Etzioni, A ;
Hartmann, E ;
von Figura, K ;
Körner, C .
NATURE GENETICS, 2001, 28 (01) :73-76
[29]   The gene defective in leukocyte adhesion deficiency II encodes a putative GDP-fucose transporter [J].
Lühn, K ;
Wild, MK ;
Eckhardt, M ;
Gerardy-Schahn, R ;
Vestweber, D .
NATURE GENETICS, 2001, 28 (01) :69-72
[30]   Golgi GDP-mannose uptake requires Leishmania LPG2 - A member of a eukaryotic family of putative nucleotide-sugar transporters [J].
Ma, DQ ;
Russell, DG ;
Beverley, SM ;
Turco, SJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (06) :3799-3805