Regulators and effectors of the ARF GTPases

被引：325

作者：

Donaldson, JG

Jackson, CL

机构：

[1] CEA Saclay, Serv Biochim & Genet Mol, F-91191 Gif Sur Yvette, France

[2] NHLBI, Cell Biol Lab, NIH, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2000年 / 12卷 / 04期

关键词：

D O I：

10.1016/S0955-0674(00)00119-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The small G proteins of the ARF family are key regulators of membrane dynamics. Many functions of ARF proteins in cells are being revealed by studies of their regulators and effecters. Significant progress has been made over the past year, with the identification of a surprisingly large family of novel ARF GTPase-activating proteins. In addition, two new classes of effecters, the PIP kinases and a novel family of monomeric coat-like proteins have been discovered.

引用

收藏

页码：475 / 482

页数：8

相关论文

共 71 条

[21] Remodeling of the actin cytoskeleton is coordinately regulated by protein kinase C and the ADP-ribosylation factor nucleotide exchange factor ARNO [J].

Frank, SR ;

Hatfield, JC ;

Casanova, JE .

MOLECULAR BIOLOGY OF THE CELL, 1998, 9 (11) :3133-3146

[22]

GEIGER C, 2000, IN PRESS EMBO J

[23] ARF mediates recruitment of PtdIns-4-OH kinase-β and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex [J].

Godi, A ;

Pertile, P ;

Meyers, R ;

Marra, P ;

Di Tullio, G ;

Iurisci, C ;

Luini, A ;

Corda, D ;

De Matteis, MA .

NATURE CELL BIOLOGY, 1999, 1 (05) :280-287

[24] Decoding of sorting signals by coatomer through a GTPase switch in the COPI coat complex [J].

Goldberg, J .

CELL, 2000, 100 (06) :671-679

[25] Structural and functional analysis of the ARF1-ARFGAP complex reveals a role for coatomer in GTP hydrolysis [J].

Goldberg, J .

CELL, 1999, 96 (06) :893-902

[26] A conserved domain of the arabidopsis GNOM protein mediates subunit interaction and cyclophilin 5 binding [J].

Grebe, M ;

Gadea, J ;

Steinmann, T ;

Kientz, M ;

Rahfeld, JU ;

Salchert, K ;

Koncz, C ;

Jürgens, G .

PLANT CELL, 2000, 12 (03) :343-356

[27] ARF1 regulates pH-dependent COP functions in the early endocytic pathway [J].

Gu, F ;

Gruenberg, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (11) :8154-8160

[28] Coatomer vesicles are not required for inhibition of Golgi transport by G-protein activators [J].

Happe, S ;

Cairns, M ;

Roth, R ;

Heuser, J ;

Weidman, P .

TRAFFIC, 2000, 1 (04) :342-353

[29] A family of proteins with γ-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome [J].

Hirst, J ;

Lui, WWY ;

Bright, NA ;

Totty, N ;

Seaman, MNJ ;

Robinson, MS .

JOURNAL OF CELL BIOLOGY, 2000, 149 (01) :67-79

[30] Phosphatidylinositol 4-phosphate 5-kinase α is a downstream effector of the small G protein ARF6 in membrane ruffle formation [J].

Honda, A ;

Nogami, M ;

Yokozeki, T ;

Yamazaki, M ;

Nakamura, H ;

Watanabe, H ;

Kawamoto, K ;

Nakayama, K ;

Morris, AJ ;

Frohman, MA ;

Kanaho, Y .

CELL, 1999, 99 (05) :521-532

← 1 2 3 4 5 6 7 8 →