IMPACT database of traumatic brain injury: Design and description

被引:161
作者
Marmarou, Anthony
Lu, Juan
Butcher, Isabella
McHugh, Gillian S.
Mushkudiani, Nino A.
Murray, Gordon D.
Steyerberg, Ewout W.
Maas, Andrew I. R.
机构
[1] Virginia Commonwealth Univ, Sch Med, Dept Neurosurg, Richmond, VA USA
[2] Univ Edinburgh, Sch Med, Edinburgh, Midlothian, Scotland
[3] Erasmus MC, Ctr Med Decis Making, Dept Publ Hlth, Rotterdam, Netherlands
[4] Erasmus MC, Dept Neurosurg, Rotterdam, Netherlands
关键词
coma; databank; head injury; IMPACT; traumatic brain injury;
D O I
10.1089/neu.2006.0036
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
The objective of this report is to describe the design and content of the International Mission for Prognosis And Clinical Trial (IMPACT) database of traumatic brain injury which contains the complete dataset from most clinical trials and organized epidemiologic studies conducted over the past 20 years. This effort, funded by the U.S. National Institutes of Health, has led to the accumulation thus far of data from 9205 patients with severe and moderate brain injuries from eight randomized placebo controlled trials and three observational studies. Data relevant to the design and analysis of pragmatic Phase III clinical trials, including pre-hospital, admission, and post-resuscitation assessments, information on the acute management, and short- and long-term outcome were merged into a top priority data set (TPDS). The major emphasis during the first phase of study is on information from time of injury to post-resuscitation and outcome at 6 months thereby providing a unique resource for prognostic analysis and for studies aimed at optimizing the design and analysis of Phase III trials in traumatic brain injury.
引用
收藏
页码:239 / 250
页数:12
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