Expression of DBC1 and SIRT1 Is Associated with Poor Prognosis of Gastric Carcinoma

被引：180

作者：

Cha, Eun Jung ^{[1
]}

Noh, Sang Jae ^{[1
]}

Kwon, Keun Sang ^{[2
]}

Kim, Chan Young ^{[3
]}

Park, Byung-Hyun ^{[4
]}

Park, Ho Sung ^{[1
]}

Lee, Ho ^{[5
,6
]}

Chung, Myoung Ja ^{[1
]}

Kang, Myoung Jae ^{[1
]}

Lee, Dong Geun ^{[1
]}

Moon, Woo Sung ^{[1
]}

Jang, Kyu Yun ^{[1
]}

机构：

[1] Chonbuk Natl Univ, Sch Med, Dept Pathol, Jeonju 561756, Jeonbuk, South Korea

[2] Chonbuk Natl Univ, Sch Med, Dept Prevent Med, Jeonju 561756, Jeonbuk, South Korea

[3] Chonbuk Natl Univ, Sch Med, Dept Gen Surg, Jeonju 561756, Jeonbuk, South Korea

[4] Chonbuk Natl Univ, Sch Med, Dept Biochem, Jeonju 561756, Jeonbuk, South Korea

[5] Chonbuk Natl Univ, Sch Med, Dept Forens Med, Res Inst Clin Med, Jeonju 561756, Jeonbuk, South Korea

[6] Chonbuk Natl Univ, Sch Med, Inst Med Sci, Jeonju 561756, Jeonbuk, South Korea

来源：

CLINICAL CANCER RESEARCH | 2009年 / 15卷 / 13期

关键词：

B-CELL LYMPHOMA; GENE-EXPRESSION; BREAST-CANCER; PROTEIN; DEACETYLASES; APOPTOSIS; SURVIVAL; CLASSIFICATION; MICROARRAY; INHIBITOR;

D O I：

10.1158/1078-0432.CCR-08-3329

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: SIRT1 (silent mating-type information regulation 2 homologue 1) expression has been reported to predict poor survival in some cancers. We therefore investigated the expression levels of SIRT1 and its negative regulator, DBC1 (deleted in breast cancer 1), in gastric cancer patients. Experimental Design: We evaluated immunohistochemical expression of DBC1, SIRT1, and p53 using 3-mm tumor cores from 177 gastric cancer patients for tissue microarray. Results: Positive expressions of DBC1 and SIRT1 were seen in 62% (109 of 177) and in 73% (130 of 177) of patients, respectively. Expression of DBC1 was significantly correlated with tumor stage (P = 0.007), lymph node metastasis (P < 0.001), tumor invasion (P = 0.001), venous invasion (P = 0.001), histologic types (P < 0.001), p53 expression (P < 0.001), and SIRT1 expression (P < 0.001). SIRT1 expression was also significantly correlated with tumor stage (P < 0.001), lymph node metastasis (P < 0.001), tumor invasion (P < 0.001), histologic types (P < 0.001), and p53 expression (P = 0.001). In addition, expression of DBC1 was significantly associated with shorter overall survival and relapse-free survival by univariate analysis (P < 0.001 and P < 0.001, respectively). SIRT1 expression was also significantly associated with shorter overall survival and relapse-free survival by univariate analysis (P = 0.001 and P = 0.001, respectively). Multivariate analysis showed that tumor stage and expression of DBC1 were independent prognostic factors significantly associated with overall survival and relapse-free survival. Conclusion: This study shows that expression of DBC1 and SIRT1 is a significant prognostic indicator for gastric carcinoma patients.

引用

页码：4453 / 4459

页数：7

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