New automated method for determining postantifungal effect of amphotericin B against Candida species:: Effects of concentration, exposure time, and area under the curve

被引：8

作者：

Chryssanthou, E

Cars, O

Sjölin, J

机构：

[1] Karolinska Hosp, Dept Clin Microbiol, S-17176 Stockholm, Sweden

[2] Univ Uppsala Hosp, Dept Med Sci, Infect Dis Sect, Antibiot Res Unit, Uppsala, Sweden

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 12期

关键词：

D O I：

10.1128/AAC.46.12.4016-4018.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The postantifungal effect (PAFE) of amphotericin B was determined with a BacT/Alert automated system, which is based on the colorimetric detection of CO2. The levels of accuracy and precision of the automated method were high. Longer PAFEs were obtained for Candida albicans (P < 0.001), C glabrata (P < 0.01), and C krusei (P < 0.01) at increasing amphotericin B concentrations and exposure times.

引用

页码：4016 / 4018

页数：3

共 9 条

[1] A PHARMACOLOGIC GUIDE TO CLINICAL USE OF AMPHOTERICIN B [J].