Fenchylamine sulfonamide inhibitors of amyloid β peptide production by the γ-secretase proteolytic pathway:: Potential small-molecule therapeutic agents for the treatment of Alzheimer's disease

被引:62
作者
Rishton, GM
Retz, DM
Tempest, PA
Novotny, J
Kahn, S
Treanor, JJS
Lile, JD
Citron, M
机构
[1] Amgen Corp, Dept Small Mol Drug Discovery, Thousand Oaks, CA 91320 USA
[2] Amgen Corp, Dept Neurobiol, Thousand Oaks, CA 91320 USA
关键词
D O I
10.1021/jm990622z
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:2297 / 2299
页数:3
相关论文
共 11 条
[1]   Polymer-supported quenching reagents for parallel purification [J].
Booth, RJ ;
Hodges, JC .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (21) :4882-4886
[2]  
BRISTOLMYERS SQUIBB, 1997, Patent No. 5703129
[3]   Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities [J].
Citron, M ;
Diehl, TS ;
Gordon, G ;
Biere, AL ;
Seubert, P ;
Selkoe, DJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (23) :13170-13175
[4]  
GIRAULT Y, 1975, B SOC CHIM FR II-CH, P385
[5]   ALZHEIMERS-DISEASE - INITIAL REPORT OF THE PURIFICATION AND CHARACTERIZATION OF A NOVEL CEREBROVASCULAR AMYLOID PROTEIN [J].
GLENNER, GG ;
WONG, CW .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (03) :885-890
[6]   VISUALIZATION OF A-BETA-42(43) AND A-BETA-40 IN SENILE PLAQUES WITH END-SPECIFIC A-BETA MONOCLONALS - EVIDENCE THAT AN INITIALLY DEPOSITED SPECIES IS A-BETA-42(43) [J].
IWATSUBO, T ;
ODAKA, A ;
SUZUKI, N ;
MIZUSAWA, H ;
NUKINA, N ;
IHARA, Y .
NEURON, 1994, 13 (01) :45-53
[7]  
ROHER AE, 1993, J BIOL CHEM, V268, P3072
[8]   Neuroscience - Alzheimer's disease: Genotypes, phenotype, and treatments [J].
Selkoe, DJ .
SCIENCE, 1997, 275 (5300) :630-631
[9]   β-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE [J].
Vassar, R ;
Bennett, BD ;
Babu-Khan, S ;
Kahn, S ;
Mendiaz, EA ;
Denis, P ;
Teplow, DB ;
Ross, S ;
Amarante, P ;
Loeloff, R ;
Luo, Y ;
Fisher, S ;
Fuller, L ;
Edenson, S ;
Lile, J ;
Jarosinski, MA ;
Biere, AL ;
Curran, E ;
Burgess, T ;
Louis, JC ;
Collins, F ;
Treanor, J ;
Rogers, G ;
Citron, M .
SCIENCE, 1999, 286 (5440) :735-741
[10]   The role of Aβ42 in Alzheimer's disease [J].
Younkin, SG .
JOURNAL OF PHYSIOLOGY-PARIS, 1998, 92 (3-4) :289-292