Types of mutations induced by glyoxal, a major oxidative DNA-damage product, in Salmonella typhimurium

被引：24

作者：

MurataKamiya, N

Kaji, H

Kasai, H

机构：

[1] UNIV OCCUPAT & ENVIRONM HLTH,INST IND ECOL SCI,DEPT ENVIRONM ONCOL,YAHATANISHI KU,KITAKYUSHU,FUKUOKA 807,JAPAN

[2] UNIV OCCUPAT & ENVIRONM HLTH,INST IND ECOL SCI,DEPT HLTH POLICY & MANAGEMENT,YAHATANISHI KU,KITAKYUSHU,FUKUOKA 807,JAPAN

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 1997年 / 377卷 / 01期

关键词：

glyoxal; oxygen radical; Ames test;

D O I：

10.1016/S0027-5107(97)00016-X

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have analyzed the types of mutations induced by glyoxal, a major oxidative DNA-damage product, in Salmonella typhimurium. A set of six strains, TA7001 to TA7006, was used to detect base-pair substitutions, and the TA98 strain was employed to detect frameshift mutations. Glyoxal did not induce mutations at A:T base pairs. The majority of the mutations induced by glyoxal were base-pair substitutions at G:C base pairs, and a small level of frameshift mutations was detected in the TA98 strain.

引用

页码：13 / 16

页数：4

共 21 条

[1]

ANDERSEN FA, 1995, J AM COLL TOXICOL, V14, P348

[2]

CHENG KC, 1992, J BIOL CHEM, V267, P166

[3] A CONTRIBUTION TO THE STUDY OF THE STRUCTURE MUTAGENICITY RELATIONSHIP FOR ALPHA-DICARBONYL COMPOUNDS USING THE AMES TEST [J].

DORADO, L ;

MONTOYA, MR ;

MELLADO, JMR .

MUTATION RESEARCH, 1992, 269 (02) :301-306

[4]

FURIHATA C, 1985, JPN J CANCER RES, V76, P809

[5] DETECTION AND CLASSIFICATION OF MUTAGENS - A SET OF BASE-SPECIFIC SALMONELLA TESTER STRAINS [J].

GEE, P ;

MARON, DM ;

AMES, BN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (24) :11606-11610

[6] THE AGING PROCESS [J].

HARMAN, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (11) :7124-7128

[7] COMPARISON OF INCORPORATION AND EXTENSION OF NUCLEOTIDES IN-VITRO OPPOSITE 8-HYDROXYGUANINE (7,8-DIHYDRO-8-OXOGUANINE) IN HOT-SPOTS OF THE C-HA-RAS GENE [J].

KAMIYA, H ;

MURATAKAMIYA, N ;

FUJIMURO, M ;

KIDO, K ;

INOUE, H ;

NISHIMURA, S ;

MASUTANI, C ;

HANAOKA, F ;

OHTSUKA, E .

JAPANESE JOURNAL OF CANCER RESEARCH, 1995, 86 (03) :270-276

[8] 8-HYDROXYGUANINE (7,8-DIHYDRO-8-OXOGUANINE) IN HOT-SPOTS OF THE C-HA-RAS GENE - EFFECTS OF SEQUENCE CONTEXTS ON MUTATION SPECTRA [J].

KAMIYA, H ;

MURATAKAMIYA, N ;

KOIZUME, S ;

INOUE, H ;

NISHIMURA, S ;

OHTSUKA, E .

CARCINOGENESIS, 1995, 16 (04) :883-889

[9] HYDROXYLATION OF DEOXYGUANOSINE AT THE C-8 POSITION BY ASCORBIC-ACID AND OTHER REDUCING AGENTS [J].

KASAI, H ;

NISHIMURA, S .

NUCLEIC ACIDS RESEARCH, 1984, 12 (04) :2137-2145

[10] GLUCOSE INHIBITION OF MUTAGENESIS BY 9-AMINOACRIDINE IN SALMONELLA-TYPHIMURIUM [J].

KOPSIDAS, G ;

MACPHEE, DG .

MUTATION RESEARCH, 1993, 285 (01) :101-108

← 1 2 3 →