Types of mutations induced by glyoxal, a major oxidative DNA-damage product, in Salmonella typhimurium

被引：24

作者：

MurataKamiya, N

Kaji, H

Kasai, H

机构：

[1] UNIV OCCUPAT & ENVIRONM HLTH,INST IND ECOL SCI,DEPT ENVIRONM ONCOL,YAHATANISHI KU,KITAKYUSHU,FUKUOKA 807,JAPAN

[2] UNIV OCCUPAT & ENVIRONM HLTH,INST IND ECOL SCI,DEPT HLTH POLICY & MANAGEMENT,YAHATANISHI KU,KITAKYUSHU,FUKUOKA 807,JAPAN

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 1997年 / 377卷 / 01期

关键词：

glyoxal; oxygen radical; Ames test;

D O I：

10.1016/S0027-5107(97)00016-X

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have analyzed the types of mutations induced by glyoxal, a major oxidative DNA-damage product, in Salmonella typhimurium. A set of six strains, TA7001 to TA7006, was used to detect base-pair substitutions, and the TA98 strain was employed to detect frameshift mutations. Glyoxal did not induce mutations at A:T base pairs. The majority of the mutations induced by glyoxal were base-pair substitutions at G:C base pairs, and a small level of frameshift mutations was detected in the TA98 strain.

引用

页码：13 / 16

页数：4