Protein architecture chronology deduced from structures of amino acid Synthases

被引：9

作者：

Ji, Hong-Fang ^{[1
]}

Zhang, Hong-Yu ^{[1
]}

机构：

[1] Shandong Univ Technol, Ctr Adv Study, Shandong Provincial Res Ctr Bioinformat Engn & Te, Zibo 255049, Peoples R China

来源：

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS | 2007年 / 24卷 / 04期

基金：

中国国家自然科学基金;

关键词：

protein; fold; evolution; and Amino Acid Synthase;

D O I：

10.1080/07391102.2007.10507122

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inferring the protein architecture chronology is one of central topics in origin of life study and has been given much attention. Based on an amino acid evolutionary model that late amino acids were bio-synthesized prior to early counterparts, we addressed the issue by examining the structures of amino acid synthases. Despite the limited structural information on amino acid synthases, our deduction revealed that alpha/beta was the oldest protein class, which is in good agreement with the prior fold-usage-based conclusion.

引用

收藏

页码：321 / 323

页数：3

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