One-pot synthesis of symmetrical and unsymmetrical bisarylethynes by a modification of the Sonogashira coupling reaction

被引：279

作者：

Mio, MJ

Kopel, LC

Braun, JB

Gadzikwa, TL

Hull, KL

Brisbois, RG

Markworth, CJ

Grieco, PA

机构：

[1] Macalester Coll, Dept Chem, St Paul, MN 55105 USA

[2] Montana State Univ, Dept Chem & Biochem, Bozeman, MT 59717 USA

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 19期

关键词：

D O I：

10.1021/ol026266n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A modification of the Sonogoshira coupling reaction employing an amidine base and a substoichiometric amount of water generates symmetrical and unsymmetrical bisarylethynylenes in one pot through in situ deprotection of trimethylsilylethynylene-added intermediates.

引用

页码：3199 / 3202

页数：4

共 29 条

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