Susceptible locus for obese type 2 diabetes mellitus in the 5′-flanking region of the tumor necrosis factor-α gene

被引：32

作者：

Kamizono, S

Yamada, K

Seki, N

Higuchi, T

Kimura, A

Nonaka, K

Itoh, K

机构：

[1] Kurume Univ, Sch Med, Dept Med, Div Endocrinol & Metab, Kurume, Fukuoka 8300011, Japan

[2] Kurume Univ, Sch Med, Dept Immunol, Kurume, Fukuoka 8300011, Japan

[3] Kurume Univ, Sch Med, Dept Pediat, Kurume, Fukuoka 8300011, Japan

[4] Tokyo Med & Dent Univ, Inst Med Res, Dept Tissue Physiol, Div Adult Dis, Tokyo, Japan

来源：

TISSUE ANTIGENS | 2000年 / 55卷 / 05期

关键词：

diabetes mellitus; obesity; polymorphism; promoter region; TNF-alpha gene;

D O I：

10.1034/j.1399-0039.2000.550508.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We have identified three novel polymorphisms in the promoter/ enhancer region of the tumor necrosis factor (TNF)-alpha gene. In this study we investigated the role of the polymorphisms in predisposition to Type 2 diabetes. The allele frequency of C-->T substitution at -857 tended to be higher in obese patients with diabetes than in lean subjects with normal glucose tolerance (0.280 vs. 0.190). This tendency was due to a significantly higher ratio of -857T homozygotes in the obese patients with diabetes (15%) than in lean subjects with normal glucose tolerance (4%). There was no significant association between polymorphisms at positions -863 or -1,013, and diabetes. The homozygous -857T.allele may be associated with genetic susceptibility to type 2 diabetes in obese subjects.

引用

页码：449 / 452

页数：4