Structural determination of three new germacrane-type sesquiterpene alcohols from curdione by microbial transformation

被引：14

作者：

Ma, Xiao-chi

Zheng, Jian

Wu, Li-jun

Guo, De-an

机构：

[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

[2] Natl Inst Control Biol & Pharmaceut Prod, Beijing 100050, Peoples R China

[3] Shenyang Pharmaceut Univ, Sch Tradit Chinese Med, Shenyang 110016, Peoples R China

来源：

MAGNETIC RESONANCE IN CHEMISTRY | 2007年 / 45卷 / 01期

关键词：

NMR; biotransformation; curdione; germacrane-type sesquiterpene;

D O I：

10.1002/mrc.1922

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Five germacrane-type sesquiterpene alcohols obtained from curdione (1) by microbial biotransformation were isolated. Their structures were characterized as (2R)-2 beta-hydroxycurdione (2), 1 alpha, 10 beta-epoxy-11-hydroxycurdione (3), (2S)-2 alpha, 11-dihydroxycurdione (4), 11,15-dihydroxycurdione (5) and (3R)-3 alpha-hydroxycurdione (6) based on the extensive NMR studies. Among them, 4, 5 and 6 are new compounds. Copyright (C) 2006 John Wiley & Sons, Ltd.

引用

页码：90 / 92

页数：3

共 10 条

[1]

Abourashed EA, 1999, CURR MED CHEM, V6, P359

[2] BIOTRANSFORMATION OF GERMACRANE-TYPE SESQUITERPENOIDS BY ASPERGILLUS-NIGER [J].