Grafting of poly(triethylene glycol dimethacrylate) onto chitosan by ceric ion initiation

Grafting of poly(triethylene glycol dimethacrylate) (poly(TriEGDMA)), onto chitosan by ceric ion initiation has been investigated. The grafting conditions were optimized by studying the effect of monomer and initiator concentrations as well as time and temperature. Products with lower grafting yields (90-261%) were water and acid soluble. Those with higher grafting yields (350-868%) were insoluble, indicating a cross linked structure. Chitosan-graft-poly(TriEGDMA) products had a lower thermal stability than chitosan as revealed by DSC analysis. C-13 NMR and FTIR analyses suggested a grafting mechanism that proceeds via oxidation and chain scission of chitosan. The products are degraded by the enzymes lysozyme, lipase and alpha-amylase-protease. (c) 2006 Elsevier B.V. All rights reserved.