MUSCLE AFTER SPINAL CORD INJURY

被引:149
作者
Biering-Sorensen, Bo [1 ,2 ]
Kristensen, Ida Brulin [1 ]
Kjaer, Michael [3 ,4 ]
Biering-Sorensen, Fin [1 ,4 ]
机构
[1] Copenhagen Univ Hosp, Clin Spinal Cord Injuries, Ctr Neurosci, Rigshosp, DK-3100 Hornbaek, Denmark
[2] Roskilde Univ Hosp, Dept Neurol, Roskilde, Denmark
[3] Copenhagen Univ Hosp, Sports Med Res Ctr, Bispebjerg Hosp, DK-3100 Hornbaek, Denmark
[4] Univ Copenhagen, Copenhagen, Denmark
关键词
contractility; morphology; muscle; paralyses; spinal cord injury; TIBIALIS ANTERIOR MUSCLE; RAT SKELETAL-MUSCLE; MEDIAL GASTROCNEMIUS FIBERS; ELECTRICAL-STIMULATION FES; GENDER-RELATED DIFFERENCES; CONTRACTILE PROPERTIES; QUADRICEPS MUSCLE; SOLEUS MUSCLE; BLOOD-FLOW; CAT SOLEUS;
D O I
10.1002/mus.21391
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The morphological and contractile changes of muscles below the level of the lesion after spinal cord injury (SCI) are dramatic. In humans with SCI, a fiber-type transformation away from type I begins 4-7 months post-SCI and reaches a new steady state with predominantly fast glycolytic IIX fibers years after the injury. There is a progressive drop in the proportion of slow myosin heavy chain (MHC) isoform fibers and a rise in the proportion of fibers that coexpress both the fast and slow MHC isoforms. The oxidative enzymatic activity starts to decline after the first few months post-SCI. Muscles from individuals with chronic SCI show less resistance to fatigue, and the speed-related contractile properties change, becoming faster. These findings are also present in animals. Future studies should longitudinally examine changes in muscles from early SCI until steady state is reached in order to determine optimal training protocols for maintaining skeletal muscle after paralysis. Muscle Nerve 40: 499-519, 2009
引用
收藏
页码:499 / 519
页数:21
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